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Literature DB >> 3840044

Acetylcholine acts on m2-muscarinic receptors to excite rat locus coeruleus neurones.

Abstract

Intracellular recordings were made from neurones of the rat locus coeruleus in vitro. Acetylcholine increased the firing rate by depolarizing the membrane; both muscarinic and nicotinic antagonists partially reduced this effect. In hexamethonium, pirenzepine shifted the acetylcholine dose-response curve to the right with an equilibrium dissociation constant of 200 nM, indicating an interaction with a m2-type of muscarinic receptor.

Entities: Chemical Species

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Year: 1985 PMID： 3840044 PMCID： PMC1916668 DOI： 10.1111/j.1476-5381.1985.tb11070.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

9 in total

1. A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea-pig atrial pacemaker cells at 29 degrees C and in ileum at 29 degrees C and 37 degrees C.

Authors: R B Barlow; K J Berry; P A Glenton; N M Nilolaou; K S Soh
Journal: Br J Pharmacol Date: 1976-12 Impact factor: 8.739

2. Binding of agonists and antagonists to muscarinic receptors.

Authors: N J Birdsall; A S Burgen; C R Hiley; E C Hulme
Journal: J Supramol Struct Date: 1976

Review 3. Neurohumoral, hormonal, and drug receptors for the lower esophageal sphincter.

Authors: R K Goyal; S Rattan
Journal: Gastroenterology Date: 1978-03 Impact factor: 22.682

4. Electrophysiological properties of neurons contained in the locus coeruleus and mesencephalic nucleus of the trigeminal nerve in vitro.

Authors: G Henderson; C M Pepper; S A Shefner
Journal: Exp Brain Res Date: 1982 Impact factor: 1.972

5. Antagonist discrimination between ganglionic and ileal muscarinic receptors.

Authors: D A Brown; A Forward; S Marsh
Journal: Br J Pharmacol Date: 1980 Impact factor: 8.739

6. Muscarinic receptor subtypes: M1 and M2 biochemical and functional characterization.

Authors: R Hammer; A Giachetti
Journal: Life Sci Date: 1982-12-27 Impact factor: 5.037

7. Some quantitative uses of drug antagonists.

Authors: O ARUNLAKSHANA; H O SCHILD
Journal: Br J Pharmacol Chemother Date: 1959-03

8. Two types of neuronal muscarine receptors modulating acetylcholine release from guinea-pig myenteric plexus.

Authors: H Kilbinger; M Nafziger
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1985-01 Impact factor: 3.000

9. Pirenzepine distinguishes between different subclasses of muscarinic receptors.

Authors: R Hammer; C P Berrie; N J Birdsall; A S Burgen; E C Hulme
Journal: Nature Date: 1980-01-03 Impact factor: 49.962

9 in total

21 in total

9. Muscarinic receptors mediating suppression of the M-current in guinea-pig olfactory cortex neurones may be of the M2-subtype.

Authors: A Constanti; J A Sim
Journal: Br J Pharmacol Date: 1987-01 Impact factor: 8.739

10. Metrifonate effects on acetylcholine and biogenic amines in rat cortex.

Authors: F Mori; G Cuadra; E Giacobini
Journal: Neurochem Res Date: 1995-09 Impact factor: 3.996

Acetylcholine acts on m2-muscarinic receptors to excite rat locus coeruleus neurones.

1. A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea-pig atrial pacemaker cells at 29 degrees C and in ileum at 29 degrees C and 37 degrees C.

2. Binding of agonists and antagonists to muscarinic receptors.

Review 3. Neurohumoral, hormonal, and drug receptors for the lower esophageal sphincter.

4. Electrophysiological properties of neurons contained in the locus coeruleus and mesencephalic nucleus of the trigeminal nerve in vitro.

5. Antagonist discrimination between ganglionic and ileal muscarinic receptors.

6. Muscarinic receptor subtypes: M1 and M2 biochemical and functional characterization.

7. Some quantitative uses of drug antagonists.

8. Two types of neuronal muscarine receptors modulating acetylcholine release from guinea-pig myenteric plexus.

9. Pirenzepine distinguishes between different subclasses of muscarinic receptors.

1. Characteristics of cholinoreceptors on identified TAN neurons of the ground snail Achatina fulica.

2. Muscarine increases cation conductance and decreases potassium conductance in rat locus coeruleus neurones.

3. Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus.

Review 4. The developmental decrease in REM sleep: the role of transmitters and electrical coupling.

Review 5. Twelfth Gaddum memorial lecture. Drug receptors and the inhibition of nerve cells.

6. Effects of biogenic amines and intravenous anesthetics on the activity of rat locus coeruleus neurons in vitro.

7. Nicotinic and muscarinic ACh receptors in rhythmically active spinal neurones in the Xenopus laevis embryo.

Review 8. The anatomical, cellular and synaptic basis of motor atonia during rapid eye movement sleep.

9. Muscarinic receptors mediating suppression of the M-current in guinea-pig olfactory cortex neurones may be of the M2-subtype.

10. Metrifonate effects on acetylcholine and biogenic amines in rat cortex.