Literature DB >> 7470751

Antagonist discrimination between ganglionic and ileal muscarinic receptors.

D A Brown, A Forward, S Marsh.   

Abstract

The effects of four antagonists on the depolarization of isolated superior cervical ganglia and the contraction of isolated ileal segments of the rat were compared. pA2 values estimated from Schild plots indicated significantly higher affinities of stercuronium (x100) and pirenzepine (x23) and a significantly lower affinity of 4-diphenylacetoxy-N-methylpiperidine methiodide (x0.39) for the ganglion than for the ileum. The affinities of N-methylscopolamine for the two tissues were not significantly different. It is concluded that the two types of muscarinic receptor are not identical.

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Year:  1980        PMID： 7470751      PMCID： PMC2044477          DOI： 10.1111/j.1476-5381.1980.tb10948.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea-pig atrial pacemaker cells at 29 degrees C and in ileum at 29 degrees C and 37 degrees C.

Authors:  R B Barlow; K J Berry; P A Glenton; N M Nilolaou; K S Soh
Journal:  Br J Pharmacol       Date:  1976-12       Impact factor: 8.739

2.  Axonal GABA-receptors in mammalian peripheral nerve trunks.

Authors:  D A Brown; S Marsh
Journal:  Brain Res       Date:  1978-11-03       Impact factor: 3.252

Review 3.  pA2 and receptor differentiation: a statistical analysis of competitive antagonism.

Authors:  R J Tallarida; A Cowan; M W Adler
Journal:  Life Sci       Date:  1979-08-20       Impact factor: 5.037

4.  The selective antimuscarinic action of stercuronium.

Authors:  C K Li; F Mitchelson
Journal:  Br J Pharmacol       Date:  1980-10       Impact factor: 8.739

5.  Three types of muscarinic receptors? [proceedings].

Authors:  R B Barlow; K N Burston; A Vis
Journal:  Br J Pharmacol       Date:  1980-01       Impact factor: 8.739

6.  Some quantitative uses of drug antagonists.

Authors:  O ARUNLAKSHANA; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1959-03

7.  Pirenzepine distinguishes between different subclasses of muscarinic receptors.

Authors:  R Hammer; C P Berrie; N J Birdsall; A S Burgen; E C Hulme
Journal:  Nature       Date:  1980-01-03       Impact factor: 49.962
  7 in total
  57 in total

1.  Muscarinic suppression of the M-current in the rat sympathetic ganglion is mediated by receptors of the M1-subtype.

Authors:  N V Marrion; T G Smart; S J Marsh; D A Brown
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

2.  A novel series of non-quaternary oxadiazoles acting as full agonists at muscarinic receptors.

Authors:  S B Freedman; E A Harley; S Patel; N R Newberry; M J Gilbert; A T McKnight; J K Tang; J J Maguire; N T Mudunkotuwa; R Baker
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739

3.  Membrane currents underlying the cholinergic slow excitatory post-synaptic potential in the rat sympathetic ganglion.

Authors:  D A Brown; A A Selyanko
Journal:  J Physiol       Date:  1985-08       Impact factor: 5.182

4.  Binding properties of nine 4-diphenyl-acetoxy-N-methyl-piperidine (4-DAMP) analogues to M1, M2, M3 and putative M4 muscarinic receptor subtypes.

Authors:  M Waelbroeck; J Camus; M Tastenoy; J Christophe
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

5.  Muscarine receptor types mediating autoinhibition of acetylcholine release and sphincter contraction in the guinea-pig iris.

Authors:  I T Bognar; M T Wesner; H Fuder
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990 Jan-Feb       Impact factor: 3.000

6.  Reversal of haemorrhagic shock in rats by cholinomimetic drugs.

Authors:  S Guarini; S Tagliavini; W Ferrari; A Bertolini
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739

7.  Muscarinic receptors discriminated by pirenzepine are involved in the regulation of neurotransmitter release in rat nucleus accumbens.

Authors:  J de Belleroche; I M Gardiner
Journal:  Br J Pharmacol       Date:  1985-10       Impact factor: 8.739

8.  M1 and M2 muscarinic receptors mediate excitation and inhibition of guinea-pig intracardiac neurones in culture.

Authors:  T G Allen; G Burnstock
Journal:  J Physiol       Date:  1990-03       Impact factor: 5.182

9.  Autoregulation of acetylcholine release from vagus nerve terminals through activation of muscarinic receptors in the dog trachea.

Authors:  Y Ito; T Yoshitomi
Journal:  Br J Pharmacol       Date:  1988-03       Impact factor: 8.739

10.  Pharmacology of the putative M4 muscarinic receptor mediating Ca-current inhibition in neuroblastoma x glioma hybrid (NG 108-15) cells.

Authors:  M P Caulfield; D A Brown
Journal:  Br J Pharmacol       Date:  1991-09       Impact factor: 8.739
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