Literature DB >> 3839095

A novel mechanism of somatic rearrangement predicted by a human T-cell antigen receptor beta-chain complementary DNA.

A D Duby, K A Klein, C Murre, J G Seidman.   

Abstract

The T-cell antigen receptor is a cell surface molecule vital in mediating the cellular immune response. The arrangement and rearrangement of the gene segments encoding the beta-chain polypeptide of the receptor are similar to those of immunoglobulin gene segments. The two constant region genes of the human T-cell antigen receptor are 8 kilobases apart with a cluster of joining segments located 5' of each constant region gene. Although most beta-chain gene rearrangements involve the variable, diversity, and joining segments, analysis of a beta-chain complementary DNA clone suggests the occasional occurrence of another type of rearrangement.

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Year:  1985        PMID： 3839095     DOI： 10.1126/science.3839095

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

1.  AKR murine thymic leukemias are from a distinct thymic cell lineage and do not express the beta chain of the T-cell antigen receptor.

Authors:  F L Owen; W M Strauss; C Murre; A D Duby; H Hiai; J G Seidman
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

2.  A joining-diversity-joining complex generated by inversion mechanism and a variable-diversity complex in the beta-chain gene of the human T-cell receptor.

Authors:  K Ikuta; T Ogura; A Shimizu; T Honjo
Journal:  Nucleic Acids Res       Date:  1986-06-25       Impact factor: 16.971

3.  Abnormal recombination products result from aberrant DNA rearrangement of the human T-cell antigen receptor beta-chain gene.

Authors:  A D Duby; J G Seidman
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

4.  Rearrangement and expression of T-cell antigen receptor genes in human T-lymphocyte tumor lines and normal human T-cell clones: evidence for allelic exclusion of Ti beta gene expression and preferential use of a J beta 2 gene segment.

Authors:  J M Leiden; D P Dialynas; A D Duby; C Murre; J Seidman; J L Strominger
Journal:  Mol Cell Biol       Date:  1986-09       Impact factor: 4.272

5.  Double-negative (CD4-CD8-) lymphocytes bearing T-cell receptor alpha and beta chains in normal human skin.

Authors:  V Groh; M Fabbi; F Hochstenbach; R T Maziarz; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

6.  Genomic sequence and organization of rabbit Tcrb constant region genes.

Authors:  N Harindranath; E Lamoyi; R G Mage
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

7.  Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis.

Authors:  A D Duby; A K Sinclair; S L Osborne-Lawrence; W Zeldes; L Kan; D A Fox
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

Review 8.  Gene rearrangements and chromosomal translocations in T cell lymphoma--diagnostic applications and their limits.

Authors:  H Griesser
Journal:  Virchows Arch       Date:  1995       Impact factor: 4.064

9.  Sequence of the D beta 2-J beta 2 region of the human T-cell receptor beta-chain locus.

Authors:  A Tunnacliffe; T H Rabbitts
Journal:  Nucleic Acids Res       Date:  1985-09-25       Impact factor: 16.971

10.  Detection of a frequent restriction fragment length polymorphism in the human T cell antigen receptor beta chain locus. A potential diagnostic tool.

Authors:  N Berliner; A D Duby; C C Morton; P Leder; J G Seidman
Journal:  J Clin Invest       Date:  1985-09       Impact factor: 14.808
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