Literature DB >> 3837191

The spliced leader sequence of Trypanosoma brucei has a potential role as a cap donor structure.

M J Lenardo, D M Dorfman, J E Donelson.   

Abstract

Trypanosoma brucei brucei and other trypanosomatid species are unique among eucaryotes because transcription of their protein-coding genes is discontinuous. The 5' ends of their mRNAs consist of an identical 35-nucleotide spliced leader which is encoded at a separate locus from that for the body of the protein-coding transcript. We show here that the spliced leader transcript contains a 5' cap structure and suggest that at least one function of the spliced leader sequence is to provide a cap structure to trypanosome mRNAs.

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Year:  1985        PMID： 3837191      PMCID： PMC366976          DOI： 10.1128/mcb.5.9.2487-2490.1985

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  19 in total

Review 1.  5' end labeling of RNA with capping and methylating enzymes.

Authors:  B Moss
Journal:  Gene Amplif Anal       Date:  1981

2.  Molecular model of a eucaryotic transcription complex: functions and movements of influenza P proteins during capped RNA-primed transcription.

Authors:  J Braam; I Ulmanen; R M Krug
Journal:  Cell       Date:  1983-09       Impact factor: 41.582

3.  Two promoters of different strengths control the transcription of the mouse alpha-amylase gene Amy-1a in the parotid gland and the liver.

Authors:  U Schibler; O Hagenbüchle; P K Wellauer; A C Pittet
Journal:  Cell       Date:  1983-06       Impact factor: 41.582

4.  Tandem repetition of the 5' mini-exon of variant surface glycoprotein genes: a multiple promoter for VSG gene transcription?

Authors:  T De Lange; A Y Liu; L H Van der Ploeg; P Borst; M C Tromp; J H Van Boom
Journal:  Cell       Date:  1983-10       Impact factor: 41.582

5.  DNA rearrangements of the variable surface antigen genes of the trypanosomes.

Authors:  W J Murphy; S T Brentano; A C Rice-Ficht; D M Dorfman; J E Donelson
Journal:  J Protozool       Date:  1984-02

6.  Transcription of viral genes by RNA polymerase II in nuclei isolated from adenovirus 2 transformed cells.

Authors:  G A Bitter; R G Roeder
Journal:  Biochemistry       Date:  1978-05-30       Impact factor: 3.162

7.  Sequences homologous to the variant antigen mRNA spliced leader are located in tandem repeats and variable orphons in trypanosoma brucei.

Authors:  R G Nelson; M Parsons; P J Barr; K Stuart; M Selkirk; N Agabian
Journal:  Cell       Date:  1983-10       Impact factor: 41.582

8.  Human genes for U2 small nuclear RNA are tandemly repeated.

Authors:  S W Van Arsdell; A M Weiner
Journal:  Mol Cell Biol       Date:  1984-03       Impact factor: 4.272

9.  Comparison of the genes coding for the common 5' terminal sequence of messenger RNAs in three trypanosome species.

Authors:  T De Lange; T M Berkvens; H J Veerman; A C Frasch; J D Barry; P Borst
Journal:  Nucleic Acids Res       Date:  1984-06-11       Impact factor: 16.971

10.  Xenopus laevis U2 snRNA genes: tandemly repeated transcription units sharing 5' and 3' flanking homology with other RNA polymerase II transcribed genes.

Authors:  I W Mattaj; R Zeller
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  13 in total

1.  Spliced leader RNA trans-splicing in dinoflagellates.

Authors:  Huan Zhang; Yubo Hou; Lilibeth Miranda; David A Campbell; Nancy R Sturm; Terry Gaasterland; Senjie Lin
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-02       Impact factor: 11.205

2.  The cap of both miniexon-derived RNA and mRNA of trypanosomes is 7-methylguanosine.

Authors:  R E Sutton; J C Boothroyd
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

3.  The structure and transcription of an element interspersed between tandem arrays of mini-exon donor RNA genes in Trypanosoma brucei.

Authors:  M Carrington; I Roditi; R O Williams
Journal:  Nucleic Acids Res       Date:  1987-12-23       Impact factor: 16.971

4.  In vitro capping in Trypanosoma cruzi identifies and shows specificity for the spliced leader RNA and U-RNAs.

Authors:  T A Zwierzynski; G A Buck
Journal:  Nucleic Acids Res       Date:  1990-07-25       Impact factor: 16.971

5.  Direct analysis of the mini-exon donor RNA of Trypanosoma brucei: detection of a novel cap structure also present in messenger RNA.

Authors:  M S Freistadt; G A Cross; A D Branch; H D Robertson
Journal:  Nucleic Acids Res       Date:  1987-12-10       Impact factor: 16.971

6.  Controlled turnover and 3' trimming of the trans splicing precursor of Trypanosoma brucei.

Authors:  P W Laird; A L ten Asbroek; P Borst
Journal:  Nucleic Acids Res       Date:  1987-12-23       Impact factor: 16.971

7.  The common 5' terminal sequence on trypanosome mRNAs: a target for anti-messenger oligodeoxynucleotides.

Authors:  A W Cornelissen; M P Verspieren; J J Toulmé; B W Swinkels; P Borst
Journal:  Nucleic Acids Res       Date:  1986-07-25       Impact factor: 16.971

8.  Many transcribed regions of the Onchocerca volvulus genome contain the spliced leader sequence of Caenorhabditis elegans.

Authors:  W L Zeng; C M Alarcon; J E Donelson
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

9.  A trans-spliced telomerase RNA dictates telomere synthesis in Trypanosoma brucei.

Authors:  Ranjodh Sandhu; Samantha Sanford; Shrabani Basu; Mina Park; Unnati M Pandya; Bibo Li; Kausik Chakrabarti
Journal:  Cell Res       Date:  2013-03-12       Impact factor: 25.617

10.  RNA-protein complexes mediate in vitro capping of the spliced-leader primary transcript and U-RNAs in Trypanosoma cruzi.

Authors:  T A Zwierzynski; G A Buck
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205
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