| Literature DB >> 3834416 |
T J Van Wimersma Greidanus, D K Donker, R Walhof, J C Van Grafhorst, N De Vries, S J Van Schaik, C Maigret, B M Spruijt, D L Colbern.
Abstract
The influence of naloxone, haloperidol and neurotensin was investigated on bombesin-induced excessive grooming in rats. All three drugs reduced the amount of bombesin-induced grooming. Haloperidol induced a general reduction in excessive grooming as induced by bombesin, without changing the composition of grooming behavior, whereas naloxone and neurotensin suppressed bombesin-induced grooming and caused a shift in the distribution of grooming elements. The main suppressive effect of these latter drugs appeared to be on the element scratching. From these data it is suggested that bombesin-induced scratching is mainly displayed by activation of opiate receptor systems, whereas the other elements of bombesin-induced excessive grooming are mainly regulated by dopaminergic systems.Entities:
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Year: 1985 PMID： 3834416 DOI： 10.1016/0196-9781(85)90447-4
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750