Literature DB >> 10482814

The effects of the phyllolitorin analogue [desTrp(3), Leu(8)]phyllolitorin on scratching induced by bombesin and related peptides in rats.

M D Johnson1, M Ko, K S Choo, J R Traynor, H I Mosberg, N N Naughton, J H Woods.   

Abstract

Bombesin along with several closely related neuropeptides elicit scratching behavior when administered centrally. The first part of the study was designed to determine the antagonistic effects of a novel phyllolitorin analogue [desTrp(3),Leu(8)]phyllolitorin (DTP) on scratching induced by three peptides (bombesin, neuromedin-C, and [Leu(8)]phyllolitorin). In addition, the binding affinity of each peptide for the bombesin receptor site was determined. DTP (30 microg) inhibited scratching induced by these peptides, but unlike the peptides, DTP had no affinity for the bombesin site, thereby suggesting that DTP is displaying physiological antagonism through an unknown mechanism.

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Year:  1999        PMID： 10482814      PMCID： PMC2863106          DOI： 10.1016/s0006-8993(99)01708-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  20 in total

1.  Behavioral effects of bombesin.

Authors:  A Cowan
Journal:  Ann N Y Acad Sci       Date:  1988       Impact factor: 5.691

2.  Studies on bombesin-induced grooming in rats.

Authors:  D E Gmerek; A Cowan
Journal:  Peptides       Date:  1983 Nov-Dec       Impact factor: 3.750

3.  ACTH-(1-24) and RX 336-M induce excessive grooming in rats through different mechanisms.

Authors:  D E Gmerek; A Cowan
Journal:  Eur J Pharmacol       Date:  1983-04-08       Impact factor: 4.432

4.  Behavioral effects of bombesin administration in rats.

Authors:  P J Kulkosky; J Gibbs; G P Smith
Journal:  Physiol Behav       Date:  1982-03

5.  [3H]diprenorphine binding to kappa-sites in guinea-pig and rat brain: evidence for apparent heterogeneity.

Authors:  M S Wood; J R Traynor
Journal:  J Neurochem       Date:  1989-07       Impact factor: 5.372

6.  Scratching behavior induced by bombesin-related peptides. Comparison of bombesin, gastrin-releasing peptide and phyllolitorins.

Authors:  A Masui; N Kato; T Itoshima; K Tsunashima; T Nakajima; N Yanaihara
Journal:  Eur J Pharmacol       Date:  1993-07-20       Impact factor: 4.432

7.  The effect of a new amphibian peptide, Leu8phyllolitorin, on thermoregulation in the rat.

Authors:  M Broccardo; A Cardamone
Journal:  Peptides       Date:  1985       Impact factor: 3.750

8.  The effects of neurotensin, naloxone and haloperidol on elements of excessive grooming behavior induced by bombesin.

Authors:  T J Van Wimersma Greidanus; D K Donker; R Walhof; J C Van Grafhorst; N De Vries; S J Van Schaik; C Maigret; B M Spruijt; D L Colbern
Journal:  Peptides       Date:  1985 Nov-Dec       Impact factor: 3.750

9.  Structure-activity relationships of mammalian bombesin-like neuropeptides in the contraction of rat uterus.

Authors:  H Mukai; H Tanaka; K Goto; K Kawai; K Yamashita; E Munekata
Journal:  Neuropeptides       Date:  1991-08       Impact factor: 3.286

10.  [D-Phe12]bombesin analogues: a new class of bombesin receptor antagonists.

Authors:  P Heinz-Erian; D H Coy; M Tamura; S W Jones; J D Gardner; R T Jensen
Journal:  Am J Physiol       Date:  1987-03
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  3 in total

1.  Characterization of scratching responses in rats following centrally administered morphine or bombesin.

Authors:  H Lee; N N Naughton; J H Woods; M C H Ko
Journal:  Behav Pharmacol       Date:  2003-11       Impact factor: 2.293

2.  The role of central gastrin-releasing peptide and neuromedin B receptors in the modulation of scratching behavior in rats.

Authors:  Pin-Yen Su; Mei-Chuan Ko
Journal:  J Pharmacol Exp Ther       Date:  2011-03-18       Impact factor: 4.030

3.  Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice.

Authors:  Devki D Sukhtankar; Mei-Chuan Ko
Journal:  PLoS One       Date:  2013-06-24       Impact factor: 3.240
  3 in total

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