Literature DB >> 3827907

Formation of phosphatidylethanol in rat brain by phospholipase D.

L Gustavsson, C Alling.   

Abstract

The mechanism of phosphatidyl [14C]ethanol formation was studied in rat brain microsomal fraction. Phospholipase D and base-exchange enzymes were assayed with [14C]ethanol as substrate. Phospholipase D was found to catalyse the formation of phosphatidylethanol. The reaction was dependent on sodium-oleate as activating factor. Phosphatidylethanol formation by phospholipase D has previously only been reported to occur in plant tissues. Stimulation of base-exchange enzymes with calcium in the presence of [14 C]ethanol did not induce any formation of phosphatidylethanol. These findings indicate that phosphatidylethanol formation in ethanol intoxicated rats is catalysed by phospholipase D.

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Year:  1987        PMID： 3827907     DOI： 10.1016/0006-291x(87)91507-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  18 in total

1.  Phosphatidylethanol Detects Moderate-to-Heavy Alcohol Use in Liver Transplant Recipients.

Authors:  Michael Francis Fleming; Matthew J Smith; Erika Oslakovic; Michael R Lucey; Jenny X Vue; Patrice Al-Saden; Josh Levitsky
Journal:  Alcohol Clin Exp Res       Date:  2017-03-20       Impact factor: 3.455

2.  Phosphatidylethanol (PEth) as a Biomarker of Alcohol Consumption in HIV-Infected Young Russian Women: Comparison to Self-Report Assessments of Alcohol Use.

Authors:  Andrew K Littlefield; Jennifer L Brown; Ralph J DiClemente; Polina Safonova; Jessica M Sales; Eve S Rose; Nikolay Belyakov; Vadim V Rassokhin
Journal:  AIDS Behav       Date:  2017-07

Review 3.  Biomarkers for detection of alcohol consumption in liver transplantation.

Authors:  Katharina Staufer; Michel Yegles
Journal:  World J Gastroenterol       Date:  2016-04-14       Impact factor: 5.742

4.  Thermotropic properties of phosphatidylethanols.

Authors:  O P Bondar; E S Rowe
Journal:  Biophys J       Date:  1996-09       Impact factor: 4.033

5.  Cloning, differential regulation and tissue distribution of alternatively spliced isoforms of ADP-ribosylation-factor-dependent phospholipase D from rat liver.

Authors:  K Katayama; T Kodaki; Y Nagamachi; S Yamashita
Journal:  Biochem J       Date:  1998-02-01       Impact factor: 3.857

Review 6.  Metabolism and functions of phosphatidylserine in mammalian brain.

Authors:  Rita Mozzi; Sandra Buratta; Gianfrancesco Goracci
Journal:  Neurochem Res       Date:  2003-02       Impact factor: 3.996

Review 7.  [What ethanol metabolites as biological markers tell us about alcohol use].

Authors:  Friedrich Martin Wurst; Natasha Thon; Wolfgang Weinmann; Michel Yegles; Ulrich Preuss
Journal:  Wien Med Wochenschr       Date:  2013-12-10

8.  Characterization of the Pharmacokinetics of Phosphatidylethanol 16:0/18:1 and 16:0/18:2 in Human Whole Blood After Alcohol Consumption in a Clinical Laboratory Study.

Authors:  Martin A Javors; Nathalie Hill-Kapturczak; John D Roache; Tara E Karns-Wright; Donald M Dougherty
Journal:  Alcohol Clin Exp Res       Date:  2016-04-30       Impact factor: 3.455

9.  Estimating driver risk using alcohol biomarkers, interlock blood alcohol concentration tests and psychometric assessments: initial descriptives.

Authors:  Paul Marques; Scott Tippetts; John Allen; Martin Javors; Christer Alling; Michel Yegles; Fritz Pragst; Friedrich Wurst
Journal:  Addiction       Date:  2009-11-16       Impact factor: 6.526

10.  Determination of phosphatidylethanol 16:0/18:1 in whole blood by 96-well supported liquid extraction and UHPLC-MS/MS.

Authors:  Thomas Berg; Elin Eliassen; Benedicte Jørgenrud; Saranda Kabashi; Alexey Petukhov; Stig Tore Bogstrand
Journal:  J Clin Lab Anal       Date:  2018-07-25       Impact factor: 2.352
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