Literature DB >> 3827829

Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters.

M Bronfman, L Amigo, M N Morales.   

Abstract

Compounds possessing the characteristics of CoA thioesters of the hypolipidaemic peroxisome proliferators clofibric acid, nafenopin and ciprofibrate were formed on incubation of the drugs with rat liver microsomal fractions, ATP and CoA. The reactivity of the drugs correlated with their pharmacological potency. It is proposed that the active species of these compounds are their acyl-CoA thioesters.

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Year:  1986        PMID： 3827829      PMCID： PMC1147356          DOI： 10.1042/bj2390781

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

1.  Tissue sulfhydryl groups.

Authors:  G L ELLMAN
Journal:  Arch Biochem Biophys       Date:  1959-05       Impact factor: 4.013

2.  Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.

Authors:  C DE DUVE; B C PRESSMAN; R GIANETTO; R WATTIAUX; F APPELMANS
Journal:  Biochem J       Date:  1955-08       Impact factor: 3.857

3.  Studies on the mechanism of the inhibitory effects of erucylcarnitine in rat heart mitochondria.

Authors:  B O Christophersen; R Z Christiansen
Journal:  Biochim Biophys Acta       Date:  1975-06-23

4.  Determination of coenzyme A and acetyl CoA in tissue extracts.

Authors:  J B Allred; D G Guy
Journal:  Anal Biochem       Date:  1969-05       Impact factor: 3.365

5.  Lipid effects of a phenolic ether (Su-13437) in the rat: comparison with CPIB.

Authors:  M M Best; C H Duncan
Journal:  Atherosclerosis       Date:  1970 Sep-Oct       Impact factor: 5.162

6.  The results of animal studies with ciprofibrate, a new orally effective hypolipidemic drug.

Authors:  A Arnold; J P McAuliff; L G Powers; D K Phillips; A L Beyler
Journal:  Atherosclerosis       Date:  1979-02       Impact factor: 5.162

7.  The participation of ethyl 4-benzyloxybenzoate (BRL 10894) and other aryl-substituted acids in glycerolipid metabolism.

Authors:  R Fears; K H Baggaley; R Alexander; B Morgan; R M Hindley
Journal:  J Lipid Res       Date:  1978-01       Impact factor: 5.922

8.  Regulation of enzymes by fatty acyl coenzyme A. Interactions of short and long chain spin-labeled acyl-CoA with the acetyl-CoA site on pig heart citrate synthase.

Authors:  B C Hansel; G L Powell
Journal:  J Biol Chem       Date:  1984-02-10       Impact factor: 5.157

9.  Acyl-CoA synthetase and the peroxisomal enzymes of beta-oxidation in human liver. Quantitative analysis of their subcellular localization.

Authors:  M Bronfman; N C Inestrosa; F O Nervi; F Leighton
Journal:  Biochem J       Date:  1984-12-15       Impact factor: 3.857

10.  The stimulation of erucate metabolism in isolated rat hepatocytes by rapeseed oil and hydrogenated marine oil-containing diets.

Authors:  R Z Christiansen; E N Christiansen; J Bremer
Journal:  Biochim Biophys Acta       Date:  1979-06-21
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  11 in total

Review 1.  Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs.

Authors:  A M Evans
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

2.  Subcellular distribution and characteristics of ciprofibroyl-CoA synthetase in rat liver. Its possible identity with long-chain acyl-CoA synthetase.

Authors:  L Amigo; M C McElroy; M N Morales; M Bronfman
Journal:  Biochem J       Date:  1992-05-15       Impact factor: 3.857

Review 3.  Fatty acid-binding protein expression in the liver: its regulation and relationship to the zonation of fatty acid metabolism.

Authors:  N M Bass
Journal:  Mol Cell Biochem       Date:  1990 Oct 15-Nov 8       Impact factor: 3.396

4.  Hypolipidaemic drugs are activated to acyl-CoA esters in isolated rat hepatocytes. Detection of drug activation by human liver homogenates and by human platelets.

Authors:  M Bronfman; M N Morales; L Amigo; A Orellana; L Nuñez; L Cárdenas; P C Hidalgo
Journal:  Biochem J       Date:  1992-05-15       Impact factor: 3.857

Review 5.  Functions of fatty acid binding proteins.

Authors:  R M Kaikaus; N M Bass; R K Ockner
Journal:  Experientia       Date:  1990-06-15

Review 6.  Mechanisms of regulation of liver fatty acid-binding protein.

Authors:  R M Kaikaus; W K Chan; P R Ortiz de Montellano; N M Bass
Journal:  Mol Cell Biochem       Date:  1993 Jun 9-23       Impact factor: 3.396

7.  The acylation of proteins by xenobiotic amphipathic carboxylic acids in cultured rat hepatocytes.

Authors:  R Hertz; J Bar-Tana
Journal:  Biochem J       Date:  1988-08-15       Impact factor: 3.857

8.  The hepatocellular transport of sulfobromophthalein-glutathione by clofibrate treated, perfused rat liver.

Authors:  D Sorrentino; R A Weisiger; N M Bass; V Licko
Journal:  Lipids       Date:  1989-05       Impact factor: 1.880

9.  Activation of a peroxisome-proliferating catabolite of cholic acid to its CoA ester.

Authors:  T Nishimaki-Mogami; A Takahashi; Y Hayashi
Journal:  Biochem J       Date:  1993-11-15       Impact factor: 3.857

10.  Interactions of inhibitors of carnitine palmitoyltransferase I and fibrates in cultured hepatocytes.

Authors:  P Gerondaes; K G Alberti; L Agius
Journal:  Biochem J       Date:  1988-07-01       Impact factor: 3.857
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