Literature DB >> 3825401

The cordycepin analogue of 2,5A and its threo isomer. Chemical synthesis, conformation and biological activity.

A Nyilas, L Vrang, A Drake, B Oberg, J Chattopadhyaya.   

Abstract

A new synthesis of the cordycepin analogue of 2,5A and its threo isomer is reported along with an assessment of their conformations by circular dichroism spectroscopy. Evidence is also presented showing that these compounds are stable against 2,5A-specific phosphodiesterase and are not able to activate the 2,5A-dependent endoribonuclease, possibly due to a reduced binding to the latter enzyme as compared to that of 2,5A.

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Year:  1986        PMID： 3825401     DOI： 10.3891/acta.chem.scand.40b-0678

Source DB:  PubMed          Journal:  Acta Chem Scand B        ISSN： 0302-4369


  4 in total

1.  Phosphorothioate and cordycepin analogues of 2',5'-oligoadenylate: inhibition of human immunodeficiency virus type 1 reverse transcriptase and infection in vitro.

Authors:  D C Montefiori; R W Sobol; S W Li; N L Reichenbach; R J Suhadolnik; R Charubala; W Pfleiderer; A Modliszewski; W E Robinson; W M Mitchell
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

2.  Chemical synthesis and biological characterization of phosphorothioate analogs of 2', 5'-3'-deoxyadenylate trimer.

Authors:  R W Sobol; R Charubala; W Pfleiderer; R J Suhadolnik
Journal:  Nucleic Acids Res       Date:  1993-05-25       Impact factor: 16.971

3.  Preparation of the individual diastereomers of adenylyl-(2'-5')-P-thioadenylyl-(2'-5')-adenosine and their 5'-phosphorylated derivatives.

Authors:  E de Vroom; A Fidder; C P Saris; G A van der Marel; J H van Boom
Journal:  Nucleic Acids Res       Date:  1987-12-10       Impact factor: 16.971

Review 4.  The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation.

Authors:  M R Player; P F Torrence
Journal:  Pharmacol Ther       Date:  1998-05       Impact factor: 12.310
  4 in total

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