What is Mooren's ulcer?

It is probable that the traditional definition of Mooren's ulcer involving relentless progression should be modified. Many eyes have been seen with corneal ulcers which have the clinical diagnosis of Mooren's ulcer but respond to varying medications and to conjunctival excision. The ulcers can progress, however, in spite of all therapy, and in these cases, we recommend removal of the remaining corneal stroma, followed by penetrating corneal transplantation. Patients with Mooren's ulcer exhibit both cell-mediated and humoral immunological phenomena but, in a small series, did not respond to immunotherapy.