Dimosthenis Mantopoulos1, Andrea Cruzat, Pedram Hamrah. 1. Cornea Service & Ocular Surface Imaging Center, Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Abstract
PURPOSE: Infectious and inflammatory corneal diseases are a major cause of blindness. To date, assessment of corneal inflammation, has only been possible by slit-lamp biomicroscopy. The purpose of this study is to review the current state of imaging technologies enabling in vivo imaging of inflammation in the cornea. METHODS: Literature review of peer-reviewed articles on in vivo imaging modalities. RESULTS: Current means of diagnosis and treatment follow-up for immune and infectious keratitis are limited to slit-lamp biomicroscopy. Several modalities are currently emerging, allowing for in vivo imaging of corneal inflammation, including in vivo confocal microscopy, anterior segment optical coherence tomography, and intravital multiphoton microscopy. CONCLUSION: Several in vivo imaging technologies are currently evolving, allowing for objective assessment of corneal inflammation and treatment response.
PURPOSE: Infectious and inflammatory corneal diseases are a major cause of blindness. To date, assessment of corneal inflammation, has only been possible by slit-lamp biomicroscopy. The purpose of this study is to review the current state of imaging technologies enabling in vivo imaging of inflammation in the cornea. METHODS: Literature review of peer-reviewed articles on in vivo imaging modalities. RESULTS: Current means of diagnosis and treatment follow-up for immune and infectious keratitis are limited to slit-lamp biomicroscopy. Several modalities are currently emerging, allowing for in vivo imaging of corneal inflammation, including in vivo confocal microscopy, anterior segment optical coherence tomography, and intravital multiphoton microscopy. CONCLUSION: Several in vivo imaging technologies are currently evolving, allowing for objective assessment of corneal inflammation and treatment response.
Authors: Francisco Pérez Bartolomé; Jorge Peraza-Nieves; J I Fernández-Vigo; Rosalía Méndez-Fernández; Julio Gonzalez Martín-Moro; Pedro Arriola-Villalobos Journal: Indian J Ophthalmol Date: 2020-08 Impact factor: 1.848
Authors: Erik H J G Aarntzen; Mangala Srinivas; Caius G Radu; Cornelis J A Punt; Otto C Boerman; Carl G Figdor; Wim J G Oyen; I Jolanda M de Vries Journal: Cell Mol Life Sci Date: 2012-10-05 Impact factor: 9.261