Literature DB >> 3818563

Extracellular phospholipase A2 activity in peritoneal cavity of casein-treated rats.

H W Chang, I Kudo, S Hara, K Karasawa, K Inoue.   

Abstract

An extracellular phospholipase A2 was detected in the peritoneal cavity of rats injected intraperitoneally with casein. This activity required Ca2+ ion and had a pH optimum of 9. The increase of phospholipase A2 activity in the peritoneal fluid as a function of time roughly paralleled the increase in the number of polymorphonuclear (PMN) leukocytes found in the peritoneal cavity. Phospholipase A2 activity was also observed in rat PMN homogenates, and its characteristics were similar to those of the enzyme found in cell-free peritoneal fluid fraction. PMN leukocytes may release non-lysozomal phospholipase A2 into the extracellular space as 'inflammation reactions' proceed.

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Year:  1986        PMID： 3818563     DOI： 10.1093/oxfordjournals.jbchem.a121791

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  8 in total

1.  Extracellular phospholipase A2 activity in cell free peritoneal lavage fluid from mice with zymosan peritonitis.

Authors:  K R Gans; S R Lundy; R L Dowling; T M Stevens; J S Kerr
Journal:  Agents Actions       Date:  1989-06

2.  Induction of cyclooxygenase protein and stimulation of prostaglandin E2 release by epidermal growth factor in cultured guinea pig gastric mucous cells.

Authors:  O Nakano; C Sakamoto; K Matsuda; Y Konda; T Matozaki; H Nishisaki; K Wada; T Suzuki; T Uchida; M Nagao
Journal:  Dig Dis Sci       Date:  1995-08       Impact factor: 3.199

3.  Characterization and pharmacological modulation of soluble phospholipase A2 generated during glycogen-induced rat peritonitis.

Authors:  L A Marshall; J Murphy; L Marinari; J Chang
Journal:  Agents Actions       Date:  1992-09

4.  Extracellular phospholipase A2 detected at inflamed sites in rats does not originate from platelets.

Authors:  H Mori; S Hara; H Mizushima; I Kudo; Y Sato; K Inoue
Journal:  Agents Actions       Date:  1991-03

5.  Proteinaceous inhibitors of phospholipase A2 purified from inflammatory sites in rats.

Authors:  Y Suwa; I Kudo; A Imaizumi; M Okada; T Kamimura; Y Suzuki; H W Chang; S Hara; K Inoue
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

6.  Effect of a new de-N-acetyl-lysoglycosphingolipid on chemically-induced inflammatory bowel disease: possible mechanism of action.

Authors:  E Tubaro; C Santiangeli; G Cavallo; L Belogi; G Guida; C Croce; A Modesti
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-12       Impact factor: 3.000

7.  Characterization of extracellular phospholipase A2 (PLA2) activity in fluid and peritoneal cells from casein-treated rats.

Authors:  T M Stevens; M McGowan; J Giannaras; J S Kerr
Journal:  Inflammation       Date:  1990-08       Impact factor: 4.092

8.  Characterization of phospholipase A2 activity in rat RPAR-induced pleurisy.

Authors:  L R Marinari; J W Berkenkopf; B M Weichman
Journal:  Agents Actions       Date:  1991-09
  8 in total

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