Literature DB >> 2508443

Extracellular phospholipase A2 activity in cell free peritoneal lavage fluid from mice with zymosan peritonitis.

K R Gans1, S R Lundy, R L Dowling, T M Stevens, J S Kerr.   

Abstract

The kinetics and appearance of extracellular phospholipase A2 (PLA2) activity and its relationship to the appearance of arachidonic acid (AA) metabolites in the peritoneal cavity of mice injected with zymosan is described. AA metabolites levels including leukotriene C4 (LTC4) were maximum 15-30 min after zymosan. Peak PLA2 activity was also found 15-30 min after zymosan and was significantly increased above levels found in saline control exudates (3.83 +/- 0.89 and 0.35 +/- 0.11, respectively, p less than or equal to 0.05). Results show that an extracellular PLA2 is present in zymosan peritonitis.

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Year:  1989        PMID： 2508443     DOI： 10.1007/bf01972817

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  6 in total

1.  Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes.

Authors:  J Weiss; P Elsbach; I Olsson; H Odeberg
Journal:  J Biol Chem       Date:  1978-04-25       Impact factor: 5.157

2.  Phospholipases and phospholipid turnover in Escherichia coli spheroplasts.

Authors:  P Patriarca; S Beckerdite; P Elsbach
Journal:  Biochim Biophys Acta       Date:  1972-04-18

3.  Intraperitoneal injection of zymosan in mice induces pain, inflammation and the synthesis of peptidoleukotrienes and prostaglandin E2.

Authors:  N S Doherty; P Poubelle; P Borgeat; T H Beaver; G L Westrich; N L Schrader
Journal:  Prostaglandins       Date:  1985-11

4.  Extracellular phospholipase A2 activity in peritoneal cavity of casein-treated rats.

Authors:  H W Chang; I Kudo; S Hara; K Karasawa; K Inoue
Journal:  J Biochem       Date:  1986-10       Impact factor: 3.387

5.  Phospholipase A2 activity in carrageenin-induced inflammatory tissue of rats.

Authors:  K Ohuchi; M Watanabe; N Numajiri; S Tsurufuji
Journal:  Biochem Pharmacol       Date:  1982-09-15       Impact factor: 5.858

6.  Inhibition of phospholipase A2 by "lipocortins" and calpactins. An effect of binding to substrate phospholipids.

Authors:  F F Davidson; E A Dennis; M Powell; J R Glenney
Journal:  J Biol Chem       Date:  1987-02-05       Impact factor: 5.157
  6 in total
  4 in total

1.  A new assay for antiphlogistic activity: zymosan-induced mouse ear inflammation.

Authors:  F Erdö; K Török; P Arányi; J I Székely
Journal:  Agents Actions       Date:  1993-07

2.  Characterization and pharmacological modulation of soluble phospholipase A2 generated during glycogen-induced rat peritonitis.

Authors:  L A Marshall; J Murphy; L Marinari; J Chang
Journal:  Agents Actions       Date:  1992-09

3.  Prostaglandin E2 requirement for transforming growth factor beta 1 inhibition of elicited macrophage 14 kDa phospholipase A2 release.

Authors:  M McCord; B Bolognese; L A Marshall
Journal:  Br J Pharmacol       Date:  1995-11       Impact factor: 8.739

4.  Characterization of phospholipase A2 activity in rat RPAR-induced pleurisy.

Authors:  L R Marinari; J W Berkenkopf; B M Weichman
Journal:  Agents Actions       Date:  1991-09
  4 in total

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