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Literature DB >> 3818358

Immunocytochemical localization of pancreatic carboxylic ester hydrolase in human paneth cells.

P Lechene de la Porte, H Lafont, D Lombardo.

Abstract

The protein-A gold method using specific rabbit sera directed against pure human pancreatic chymotrypsinogen and carboxylic ester hydrolase was applied to locate these (pro)enzymes in human pancreatic acinar cells and intestinal Paneth cells. Quantitative evaluation of the labelling indicated that both (pro)enzymes are present in pancreatic acinar secretory granules. In Paneth cell secretory granules, only carboxylic ester hydrolase was present in significant amounts, although the labelling for this enzyme was less intense than that observed in pancreatic zymogen granules. The results obtained support the view that Paneth cells represent a "diffuse exocrine gland" scattered along the intestine, whose role is either to act as a substitute in the event of a deficient pancreas or to regulate the intestinal flora.

Entities: Disease Species

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Year: 1986 PMID： 3818358 DOI： 10.1007/bf00493390

Source DB: PubMed Journal: Histochemistry ISSN： 0301-5564

30 in total

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Authors: D P Muller; J A Manning; P M Mathias; J T Harries
Journal: Int J Vitam Nutr Res Date: 1976 Impact factor: 1.784

2. Localization of lysozyme activity in a Paneth cell granule fraction.

Authors: R J Deckx; G R Vantrappen; M M Parein
Journal: Biochim Biophys Acta Date: 1967-05-16

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Authors: B Hadorn; N Steiner; C Sumida; T J Peters
Journal: Lancet Date: 1971-01-23 Impact factor: 79.321

4. Obligatory role of bile for the intestinal absorption of vitamin E.

Authors: H E Gallo-Torres
Journal: Lipids Date: 1970-04 Impact factor: 1.880

5. Carboxyl ester hydrolase and lipase of human pancreatic juice and intestinal content. Behaviour in gel filtration.

Authors: C Erlanson; B Borgström
Journal: Scand J Gastroenterol Date: 1970 Impact factor: 2.423

6. Immunocytochemical localization of exocrine enzymes in rat pancreatic acinar carcinoma.

Authors: M Bendayan; M J Becich; J K Reddy
Journal: Eur J Cell Biol Date: 1984-05 Impact factor: 4.492

7. Novel intestinal phospholipase A2: purification and some molecular characteristics.

Authors: R Verger; F Ferrato; C M Mansbach; G Pieroni
Journal: Biochemistry Date: 1982-12-21 Impact factor: 3.162

8. Histological variations of the duodenal mucosa in chronic human pancreatitis.

Authors: F Senegas-Balas; M J Bastie; D Balas; J Escourrou; G Bommelaer; C Bertrand; Y Arany; A Ribet
Journal: Dig Dis Sci Date: 1982-10 Impact factor: 3.199

9. Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. I. Action on carboxyl esters, glycerides and phospholipids.

Authors: D Lombardo; J Fauvel; O Guy
Journal: Biochim Biophys Acta Date: 1980-01-11

10. The effect of pancreatic diversion on lymphatic absorption and esterification of cholesterol in the rat.

Authors: S M Watt; W J Simmonds
Journal: J Lipid Res Date: 1981-01 Impact factor: 5.922

8 in total

1. Crystalloid lysozyme inclusions in Paneth cells of vitamin A-deficient rats.

Authors: M J Koch; H K Biesalski; E Stofft; H Weiser; H E Gabbert; H P Dienes; B Schulz-Dobrick; K H Bässler
Journal: Cell Tissue Res Date: 1990-05 Impact factor: 5.249

2. Changes in cell proliferation and differentiation of adult rat small intestine epithelium after adrenalectomy: kinetic, biochemical, and morphological studies.

Authors: B Foligne; S Aissaoui; F Senegas-Balas; C Cayuela; P Bernard; J M Antoine; D Balas
Journal: Dig Dis Sci Date: 2001-06 Impact factor: 3.199

Immunocytochemical localization of pancreatic carboxylic ester hydrolase in human paneth cells.

1. Studies on the intestinal hydrolysis of tocopheryl esters.

2. Localization of lysozyme activity in a Paneth cell granule fraction.

3. Intestinal enterokinase. Mechanisms of tts "secretion" into the lumen of the small intestine.

4. Obligatory role of bile for the intestinal absorption of vitamin E.

5. Carboxyl ester hydrolase and lipase of human pancreatic juice and intestinal content. Behaviour in gel filtration.

6. Immunocytochemical localization of exocrine enzymes in rat pancreatic acinar carcinoma.

7. Novel intestinal phospholipase A2: purification and some molecular characteristics.

8. Histological variations of the duodenal mucosa in chronic human pancreatitis.

9. Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. I. Action on carboxyl esters, glycerides and phospholipids.

10. The effect of pancreatic diversion on lymphatic absorption and esterification of cholesterol in the rat.

1. Crystalloid lysozyme inclusions in Paneth cells of vitamin A-deficient rats.

2. Changes in cell proliferation and differentiation of adult rat small intestine epithelium after adrenalectomy: kinetic, biochemical, and morphological studies.

3. Exocrine pancreatic secretion in the elderly.

4. Effect of live and heat-killed bacteria on the secretory activity of Paneth cells in germ-free mice.

5. Cell-specific expression of alpha 1-antitrypsin in human intestinal epithelium.

6. Immunocytochemical localization of pancreatitis-associated protein in human small intestine.

7. Carboxyl ester lipase in human tissues and in acute pancreatitis.

8. Tumor necrosis factor mRNA localized to Paneth cells of normal murine intestinal epithelium by in situ hybridization.