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Literature DB >> 2963697

Effect of live and heat-killed bacteria on the secretory activity of Paneth cells in germ-free mice.

Abstract

Germ-free mice were given live or heat-killed facultative anaerobes, and the ultrastructure of ileal Paneth cells was quantitatively examined with special reference to secretory granules showing a bipartite substructure (central core and peripheral halo). After administering live or heat-killed bacteria, there was a decrease in the area occupied by the cores of secretory granules in Paneth cells, and exocytosed core material was observed in the crypt lumen. There were no changes in the area occupied by the halo of secretory granules. None of the examined Paneth cells phagocytosed bacteria. It is concluded that certain bacteria may affect the secretion of antibacterial agents contained in the secretory granules of Paneth cells.

Entities: Species

Mesh：

Year: 1988 PMID： 2963697 DOI： 10.1007/bf00215451

Source DB: PubMed Journal: Cell Tissue Res ISSN： 0302-766X Impact factor: 5.249

37 in total

1. Localization of lysozyme activity in a Paneth cell granule fraction.

Authors: R J Deckx; G R Vantrappen; M M Parein
Journal: Biochim Biophys Acta Date: 1967-05-16

2. Acid mucosubstance and basic protein in mouse Paneth cells.

Authors: S S Spicer; M W Staley; M G Wetzel; B K Wetzel
Journal: J Histochem Cytochem Date: 1967-04 Impact factor: 2.479

3. Comparative effects of CCK-PZ on certain intestinal hydrolases in the mucosa and in the luminal content of the hamster jejuno-ileum.

Authors: F Senegas-Balas; D Balas; L Pradayrol; J Laval; A Ribet
Journal: Acta Hepatogastroenterol (Stuttg) Date: 1979-12

4. Studies of the substructures of the lysozyme-rich secretory granule of the serous cell in the human nasal gland.

Authors: M Machino; H Morioka; M Tachibana; T Tsuruoka; O Mizukoshi
Journal: Arch Histol Jpn Date: 1984-11

5. Tracheal submucosal gland serous cells stimulated in vitro with adrenergic and cholinergic agonists. A morphometric study.

Authors: C B Basbaum; I Ueki; L Brezina; J A Nadel
Journal: Cell Tissue Res Date: 1981 Impact factor: 5.249

6. Immunoglobulins within human small-intestinal Paneth cells.

Authors: C B Rodning; I D Wilson; S L Erlandsen
Journal: Lancet Date: 1976-05-08 Impact factor: 79.321

7. Influence of conventionalization on small-intestinal mucosa of germ-free Wistar rats: quantitative light microscopic observations.

Authors: K Ishikawa; Y Satoh; H Tanaka; K Ono
Journal: Acta Anat (Basel) Date: 1986

8. Light and electron microscopic histochemistry of the serous secretory granules in the salivary glandular cells of the mongolian gerbil (Mongolian meridianus) and rhesus monkey (Macaca irus).

Authors: M Ichikawa; A Ichikawa
Journal: Anat Rec Date: 1977-09

Effect of live and heat-killed bacteria on the secretory activity of Paneth cells in germ-free mice.

1. Localization of lysozyme activity in a Paneth cell granule fraction.

2. Acid mucosubstance and basic protein in mouse Paneth cells.

3. Comparative effects of CCK-PZ on certain intestinal hydrolases in the mucosa and in the luminal content of the hamster jejuno-ileum.

4. Studies of the substructures of the lysozyme-rich secretory granule of the serous cell in the human nasal gland.

5. Tracheal submucosal gland serous cells stimulated in vitro with adrenergic and cholinergic agonists. A morphometric study.

6. Immunoglobulins within human small-intestinal Paneth cells.

7. Influence of conventionalization on small-intestinal mucosa of germ-free Wistar rats: quantitative light microscopic observations.

8. Light and electron microscopic histochemistry of the serous secretory granules in the salivary glandular cells of the mongolian gerbil (Mongolian meridianus) and rhesus monkey (Macaca irus).

9. Quantitative electron microscopic observations on Paneth cells of germfree and ex-germfree Wistar rats.

10. Immunohistochemical localization of intestinal phospholipase A2 in rat paneth cells.

1. Induction of a rat enteric defensin gene by hemorrhagic shock.

2. Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins.

3. The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance.

4. Paneth cell degranulation and lysozyme secretion during acute equine alimentary laminitis.

5. Localization of human intestinal defensin 5 in Paneth cell granules.

6. Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria.

7. Secretion of type II phospholipase A2 and cryptdin by rat small intestinal Paneth cells.

8. Bethanechol and a G-protein activator, NaF/AlCl3, induce secretory response in Paneth cells of mouse intestine.

9. Atropine inhibits the degranulation of Paneth cells in ex-germ-free mice.

10. Cryptdins: antimicrobial defensins of the murine small intestine.