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Literature DB >> 3818227

Aminoglutethimide. Penetration of the blood brain barrier.

C Unger, H Eibl, H W von Heyden, D J Kim, G A Nagel.

Abstract

The uptake of 14C-labeled aminoglutethimide into the brain was investigated in the rat after intracarotid injection according to the method of Oldendorf, as well as in cisternal cerebrospinal fluid obtained by suboccipital puncture after i.v. injection of the drug. The brain uptake index of aminoglutethimide after intracarotid injection was 30.7 + 2.4%. Cerebrospinal fluid/blood quotients after i.v. drug injection were 0.53 at 10 min and 0.26 at 60 min. The results of both methods clearly show that aminoglutethimide easily penetrates the blood brain barrier.

Entities: Chemical Species

Mesh：

Substances：
Aminoglutethimide

Year: 1986 PMID： 3818227 DOI： 10.1007/bf00179589

Source DB: PubMed Journal: Invest New Drugs ISSN： 0167-6997 Impact factor: 3.850

8 in total

1. Lipid solubility and drug penetration of the blood brain barrier.

Authors: W H Oldendorf
Journal: Proc Soc Exp Biol Med Date: 1974-12

2. Oestradiol synthesis by a human breast carcinoma.

Authors: W R Miller; A P Forrest
Journal: Lancet Date: 1974-10-12 Impact factor: 79.321

3. Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard.

Authors: W H Oldendorf
Journal: Brain Res Date: 1970-12-01 Impact factor: 3.252

4. Suboccipital puncture of guinea pigs.

Authors: H Reiber; O Schunck
Journal: Lab Anim Date: 1983-01 Impact factor: 2.471

5. The conversion of androstenedione to estrone, estradiol, and testosterone in breast tissue.

Authors: E Perel; D Wilkins; D W Killinger
Journal: J Steroid Biochem Date: 1980-01 Impact factor: 4.292

6. Estrogen synthesis and estradiol binding by human mammary tumors.

Authors: R M Varela; T L Dao
Journal: Cancer Res Date: 1978-08 Impact factor: 12.701

7. Aromatization of androgens by muscle and adipose tissue in vivo.

Authors: C Longcope; J H Pratt; S H Schneider; S E Fineberg
Journal: J Clin Endocrinol Metab Date: 1978-01 Impact factor: 5.958

8. Aromatization of androgens by human breast cancer.

Authors: Y J Abul-Hajj; R Iverson; D T Kiang
Journal: Steroids Date: 1979-02 Impact factor: 2.668

8 in total

5 in total

Aminoglutethimide. Penetration of the blood brain barrier.

1. Lipid solubility and drug penetration of the blood brain barrier.

2. Oestradiol synthesis by a human breast carcinoma.

3. Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard.

4. Suboccipital puncture of guinea pigs.

5. The conversion of androstenedione to estrone, estradiol, and testosterone in breast tissue.

6. Estrogen synthesis and estradiol binding by human mammary tumors.

7. Aromatization of androgens by muscle and adipose tissue in vivo.

8. Aromatization of androgens by human breast cancer.

1. Tissue distribution and elimination of 14C-aminoglutethimide in the mouse.

2. Comparison of the blood-brain barrier and liver penetration of acridine antitumor drugs.

3. Brain uptake and CNS levels of 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)urea (HECNU).

4. Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons.

5. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways.