Literature DB >> 3436741

Brain uptake and CNS levels of 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)urea (HECNU).

C Unger1, H Eibl, J Engel, G A Nagel, G Eisenbrand.   

Abstract

The uptake of 14C-labeled 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)urea (HECNU) into the brain was investigated in the rat after intracarotid injection according to the method of OLDENDORF, as well as in cisternal cerebrospinal fluid obtained by suboccipital puncture after i.v. injection of the drug. The brain uptake index was 31.9 +/- 2.9%. Cerebrospinal fluid/blood quotients after i.v. injection were 0.82 at 10 min and 1.10 at 60 min. The results of both methods clearly show that HECNU, in spite of its hydrophilic property, easily penetrates the blood-brain barrier.

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Year:  1987        PMID： 3436741     DOI： 10.1007/BF00169975

Source DB:  PubMed          Journal:  Invest New Drugs        ISSN： 0167-6997            Impact factor:   3.850


  6 in total

1.  [Blood-brain barrier and the penetration of cytostatic drugs].

Authors:  C Unger; H Eibl; H W von Heyden; B Krisch; G A Nagel
Journal:  Klin Wochenschr       Date:  1985-06-18

2.  Lipid solubility and drug penetration of the blood brain barrier.

Authors:  W H Oldendorf
Journal:  Proc Soc Exp Biol Med       Date:  1974-12

3.  Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard.

Authors:  W H Oldendorf
Journal:  Brain Res       Date:  1970-12-01       Impact factor: 3.252

4.  Suboccipital puncture of guinea pigs.

Authors:  H Reiber; O Schunck
Journal:  Lab Anim       Date:  1983-01       Impact factor: 2.471

5.  Chemotherapeutic activity of new 2-chloroethylnitrosoureas in rat L5222 leukemia: comparison of bifunctional and water-soluble derivatives with 1,3-bis(2-chloroethyl)-1-nitrosourea.

Authors:  W J Zeller; G Eisenbrand; H H Fiebig
Journal:  J Natl Cancer Inst       Date:  1978-02       Impact factor: 13.506

6.  Aminoglutethimide. Penetration of the blood brain barrier.

Authors:  C Unger; H Eibl; H W von Heyden; D J Kim; G A Nagel
Journal:  Invest New Drugs       Date:  1986       Impact factor: 3.850
  6 in total

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