Literature DB >> 3816968

Attenuation of endothelium-dependent relaxation in aorta from diabetic rats.

Y Oyama, H Kawasaki, Y Hattori, M Kanno.   

Abstract

Endothelium-dependent relaxation was examined in aortic ring preparations obtained from rats with streptozotocin-induced diabetes. The endothelium-dependent relaxation which was produced by acetylcholine and histamine in aortic rings precontracted with norepinephrine was significantly attenuated in aortic rings from diabetic rats when compared with the relaxation in rings from age-matched control animals. However, the relaxation induced by sodium nitroprusside (an endothelium-independent relaxant agent) in diabetic preparations was comparable to the control. These results show that diabetes leads to an impairment of the endothelium-dependent relaxation of aorta.

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Year:  1986        PMID： 3816968     DOI： 10.1016/0014-2999(86)90013-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  63 in total

1.  Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

Authors:  B Tesfamariam; M L Brown; R A Cohen
Journal:  J Clin Invest       Date:  1991-05       Impact factor: 14.808

2.  Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant.

Authors:  P Rösen; T Ballhausen; W Bloch; K Addicks
Journal:  Diabetologia       Date:  1995-10       Impact factor: 10.122

3.  The endothelium-dependent relaxation of human middle cerebral artery: effects of activated neutrophils.

Authors:  S E Akopov; M R Grigorian; E S Gabrielian
Journal:  Experientia       Date:  1992-01-15

4.  Impaired forearm vasodilatation by acetylcholine in patients with hypertension.

Authors:  M Yoshida; T Imaizumi; S Ando; Y Hirooka; S Harada; A Takeshita
Journal:  Heart Vessels       Date:  1991       Impact factor: 2.037

Review 5.  Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction.

Authors:  Csaba Szabo
Journal:  Br J Pharmacol       Date:  2009-02-06       Impact factor: 8.739

6.  Mechanisms underlying the attenuation of endothelium-dependent vasodilatation in the mesenteric arterial bed of the streptozotocin-induced diabetic rat.

Authors:  A Makino; K Ohuchi; K Kamata
Journal:  Br J Pharmacol       Date:  2000-06       Impact factor: 8.739

7.  Mechanisms underlying the chronic pravastatin treatment-induced improvement in the impaired endothelium-dependent aortic relaxation seen in streptozotocin-induced diabetic rats.

Authors:  T Kobayashi; T Matsumoto; K Kamata
Journal:  Br J Pharmacol       Date:  2000-09       Impact factor: 8.739

8.  High-glucose incubation of human umbilical-vein endothelial cells does not alter expression and function either of G-protein alpha-subunits or of endothelial NO synthase.

Authors:  G Mancusi; C Hutter; S Baumgartner-Parzer; K Schmidt; W Schütz; V Sexl
Journal:  Biochem J       Date:  1996-04-01       Impact factor: 3.857

9.  Impairment of nitrergic-mediated relaxation of rat isolated duodenum by experimental diabetes.

Authors:  M A Martinez-Cuesta; H Massuda; B J Whittle; S Moncada
Journal:  Br J Pharmacol       Date:  1995-03       Impact factor: 8.739

10.  The phosphodiesterase-5 inhibitor vardenafil improves cardiovascular dysfunction in experimental diabetes mellitus.

Authors:  T Radovits; T Bömicke; G Kökény; R Arif; S Loganathan; K Kécsán; S Korkmaz; E Barnucz; P Sandner; M Karck; G Szabó
Journal:  Br J Pharmacol       Date:  2009-03-04       Impact factor: 8.739
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