Literature DB >> 3815518

Histone H2B repression causes cell-cycle-specific arrest in yeast: effects on chromosomal segregation, replication, and transcription.

M Han, M Chang, U J Kim, M Grunstein.   

Abstract

To determine which cellular processes are dependent on histones, we blocked histone H2B mRNA synthesis in asynchronously growing yeast after fusing the H2B gene to a repressible GAL10 promoter. Chromosomal segregation, replication, and transcription were then examined. We found that the cells arrested in mitosis, with a cell division cycle (cdc) phenotype. Chromatin structure and nuclear segregation were disrupted. A full round of DNA replication took place after the repression of histone H2B mRNA synthesis. Active transcription and the induction of new transcripts also continued in the arrested cells.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3815518     DOI： 10.1016/0092-8674(87)90237-6

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  69 in total

1.  Nucleosome depletion alters the chromatin structure of Saccharomyces cerevisiae centromeres.

Authors:  M J Saunders; E Yeh; M Grunstein; K Bloom
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

2.  The highly conserved N-terminal domains of histones H3 and H4 are required for normal cell cycle progression.

Authors:  B A Morgan; B A Mittman; M M Smith
Journal:  Mol Cell Biol       Date:  1991-08       Impact factor: 4.272

3.  Excess histone levels mediate cytotoxicity via multiple mechanisms.

Authors:  Rakesh Kumar Singh; Dun Liang; Ugander Reddy Gajjalaiahvari; Marie-Helene Miquel Kabbaj; Johanna Paik; Akash Gunjan
Journal:  Cell Cycle       Date:  2010-10-13       Impact factor: 4.534

4.  Chromatin assembly in a yeast whole-cell extract.

Authors:  M C Schultz; D J Hockman; T A Harkness; W I Garinther; B A Altheim
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

5.  Defective histone supply causes changes in RNA polymerase II elongation rate and cotranscriptional pre-mRNA splicing.

Authors:  Silvia Jimeno-González; Laura Payán-Bravo; Ana M Muñoz-Cabello; Macarena Guijo; Gabriel Gutierrez; Félix Prado; José C Reyes
Journal:  Proc Natl Acad Sci U S A       Date:  2015-11-17       Impact factor: 11.205

Review 6.  Chromatin and DNA replication.

Authors:  David M MacAlpine; Geneviève Almouzni
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-08-01       Impact factor: 10.005

7.  Drosophila lipid droplets buffer the H2Av supply to protect early embryonic development.

Authors:  Zhihuan Li; Matthew R Johnson; Zhonghe Ke; Lili Chen; Michael A Welte
Journal:  Curr Biol       Date:  2014-06-12       Impact factor: 10.834

8.  Nucleosome loss activates CUP1 and HIS3 promoters to fully induced levels in the yeast Saccharomyces cerevisiae.

Authors:  L K Durrin; R K Mann; M Grunstein
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

9.  A mutation in NPS1/STH1, an essential gene encoding a component of a novel chromatin-remodeling complex RSC, alters the chromatin structure of Saccharomyces cerevisiae centromeres.

Authors:  E Tsuchiya; T Hosotani; T Miyakawa
Journal:  Nucleic Acids Res       Date:  1998-07-01       Impact factor: 16.971

Review 10.  WEE1 tyrosine kinase, a novel epigenetic modifier.

Authors:  Kiran Mahajan; Nupam P Mahajan
Journal:  Trends Genet       Date:  2013-03-26       Impact factor: 11.639
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.