Literature DB >> 3813653

Effects of 12-o-tetradecanoylphorbol-13-acetate and polyprenoic acid derivative on calcium-activated phospholipid-dependent protein kinase of pig skin.

H Koizumi, H Suya, O Nemoto, T Aoyagi, A Ohkawara.   

Abstract

12-o-Tetradecanoylphorbol-13-acetate (TPA) activates calcium-activated, phospholipid-dependent protein kinase (protein kinase C) partially purified in an ion exchange column from pig epidermis. Protein kinase C was activated by TPA in a concentration-dependent manner with simultaneous addition of Ca2+ and phospholipid. Polyprenoic acid derivative (E5166) which is a newly synthesized retinoic acid derivative, inhibited the TPA activation of protein kinase C. This inhibition may explain the mechanisms by which retinoids inhibit TPA-induced tumor promotion.

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Year:  1986        PMID： 3813653     DOI： 10.1007/bf00404358

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  23 in total

1.  The modulating effect of retinoids and a tumor promoter on malignant transformation, sister chromatid exchanges, and Na/K ATPase.

Authors:  C Borek; R C Miller; C R Geard; D Guernsey; R S Osmak; M Rutledge-Freeman; A Ong; H Mason
Journal:  Ann N Y Acad Sci       Date:  1981-02-27       Impact factor: 5.691

2.  Phorbol diester receptor copurifies with protein kinase C.

Authors:  J E Niedel; L J Kuhn; G R Vandenbark
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

3.  Retinol inhibition of ornithine decarboxylase induction and G1 progression in Chinese hamster ovary cells.

Authors:  M K Haddox; K F Scott; D H Russell
Journal:  Cancer Res       Date:  1979-12       Impact factor: 12.701

4.  Calcium-activated, phospholipid-dependent protein kinase in pig epidermis.

Authors:  H Koizumi; K Adachi; M Tsutsui; S Itami; H Katayama; K M Halprin
Journal:  J Invest Dermatol       Date:  1984-10       Impact factor: 8.551

5.  Retinal inhibits TPA activated, calcium-dependent, phospholipid-dependent protein kinase ("C" kinase).

Authors:  S M Taffet; A R Greenfield; M K Haddox
Journal:  Biochem Biophys Res Commun       Date:  1983-08-12       Impact factor: 3.575

6.  Characterization of cytosolic calcium-activated phospholipid-dependent protein kinase activity in embryonal carcinoma cells. Effect of retinoc acid-induced differentiation of F9 cells to parietal endoderm.

Authors:  A S Kraft; W B Anderson
Journal:  J Biol Chem       Date:  1983-08-10       Impact factor: 5.157

7.  Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

Authors:  M Castagna; Y Takai; K Kaibuchi; K Sano; U Kikkawa; Y Nishizuka
Journal:  J Biol Chem       Date:  1982-07-10       Impact factor: 5.157

8.  Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

Authors:  A Kishimoto; Y Takai; T Mori; U Kikkawa; Y Nishizuka
Journal:  J Biol Chem       Date:  1980-03-25       Impact factor: 5.157

9.  Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

Authors:  Y Takai; A Kishimoto; Y Iwasa; Y Kawahara; T Mori; Y Nishizuka
Journal:  J Biol Chem       Date:  1979-05-25       Impact factor: 5.157

10.  Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C.

Authors:  J A Rillema
Journal:  Proc Soc Exp Biol Med       Date:  1985-03
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