Literature DB >> 381315

Potentiation of the chemotherapeutic action of 5-fluorouracil by combination with cytidine or guanosine on HRS-sarcoma.

H Osswald, M Youssef.   

Abstract

The chemotherapeutic action of 5-fluorouracil monotherapy on HRS-Sarcoma in mice was compared with those of 5-fluorouracil nucleoside combinations (thymidine, cytidine or guanosine). The curative action of 5-fluorouracil was potentiated without increasing its toxicity, when cytidine or guanosine were applied at definite intervals before or after 5-fluorouracil.

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Year:  1979        PMID： 381315     DOI： 10.1007/bf00964579

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  9 in total

1.  Studies of fluorinated pyrimidines. XV. Inhibition of the incorporation of formate-C14 into DNA thymine of Ehrlich ascites carcinoma cells by 5-fluoro-2'-deoxyuridine-5'-monophosphate and related compounds.

Authors:  K L MUKHERJEE; C HEIDELBERGER
Journal:  Cancer Res       Date:  1962-08       Impact factor: 12.701

2.  Potentiation by guanine nucleosides of the growth-inhibitory effects of adenosine analogs on L1210 and sarcoma 180 cells in culture.

Authors:  G B Grindey; J K Lowe; A Y Divekar; M T Hakala
Journal:  Cancer Res       Date:  1976-02       Impact factor: 12.701

3.  5-Fluorouracil and derivatives in cancer chemotherapy. II. Possible in vivo formation and stabilization of 5-fluoro-2'-deoxyuridine.

Authors:  J J Windheuser; J Jato
Journal:  J Pharm Sci       Date:  1972-10       Impact factor: 3.534

4.  [Synergistic effect of the combination of thymidine and cyclophosphamide on Ehrlich ascites tumor].

Authors:  H Osswald
Journal:  Z Krebsforsch       Date:  1970

5.  Metabolic conditioning and metabolic actuation: experimental approaches to cancer chemotherapy involving combinations of metabolites and antimetabolites.

Authors:  A Bloch
Journal:  Cancer Chemother Rep       Date:  1974 Jul-Aug

6.  [Potentiation of the chemotherapeutic effect of vinblastine by thymidine].

Authors:  H Osswald
Journal:  Arzneimittelforschung       Date:  1972-08

7.  [Overadditive synergism of combinations of cyclophosphamide with thymidine, adenosine or uridine in transplantation tumors].

Authors:  H Osswald
Journal:  Arzneimittelforschung       Date:  1972-07

8.  [Clinical experiences with a combination therapy of metastasising genital and mammary carcinomas (author's transl)].

Authors:  A Brachetti; A Leonhardt; H Limburg; H Osswald; D Schmähl
Journal:  MMW Munch Med Wochenschr       Date:  1974-11-22

9.  Potentiation of the chemotherapeutic action of bleomycin by combination with inosine on HRS-sarcoma.

Authors:  H Osswald; M Youssef
Journal:  Cancer Lett       Date:  1975-09       Impact factor: 8.679
  9 in total
  4 in total

1.  Elevation of plasma levels of fluorinated pyrimidines by guanosine 5'-monophosphate.

Authors:  M Iigo; Z Yamaizumi; S Nishimura; A Hoshi
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

2.  Overadditive chemotherapeutic synergism of prospidine and inosine when given sequentially to the Sarcoma 180 implanted intramuscularly.

Authors:  H Osswald; M Youssef
Journal:  J Cancer Res Clin Oncol       Date:  1980-01       Impact factor: 4.553

3.  Effect of guanosine on antitumor activity of fluorinated pyrimidines against P 388 leukemia.

Authors:  M Iigo; A Hoshi
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

4.  Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine.

Authors:  H R Hartmann; W Bollag
Journal:  Med Oncol Tumor Pharmacother       Date:  1986
  4 in total

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