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Literature DB >> 7358769

Overadditive chemotherapeutic synergism of prospidine and inosine when given sequentially to the Sarcoma 180 implanted intramuscularly.

Abstract

The chemotherapeutic effectiveness of prospidine monotherapy on the Sarcoma 180 implanted i.m. was compared with several prospidine/inosine combinations. The chemotherapeutic action of the combination was enhanced overadditively when inosine was given 6 h after prospidine. This particular combination caused not only a significant curative action and tumor inhibition as compared with prospidine monotherapy, but also decreased the toxic effects.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1980 PMID： 7358769 DOI： 10.1007/bf00412902

Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553

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References

14 in total

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Authors: H Osswald
Journal: Arzneimittelforschung Date: 1972-07

Overadditive chemotherapeutic synergism of prospidine and inosine when given sequentially to the Sarcoma 180 implanted intramuscularly.

1. [Synergistic effect of the combination of thymidine and cyclophosphamide on Ehrlich ascites tumor].

2. [Antineoplastic and antimitotic effect of prospidin in hypophysectomized and thyroidectomized rats with sarcoma 45].

3. Metabolic conditioning and metabolic actuation: experimental approaches to cancer chemotherapy involving combinations of metabolites and antimetabolites.

4. [Potentiation of the chemotherapeutic effect of vinblastine by thymidine].

5. [Overadditive synergism of combinations of cyclophosphamide with thymidine, adenosine or uridine in transplantation tumors].

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