Literature DB >> 3806800

Instability of large direct repeats in retrovirus vectors.

B W Rhode, M Emerman, H M Temin.   

Abstract

Retrovirus vectors were constructed with large (0.85- to 1.3-kilobase-pair) direct repeats in their genomes. Deletions involving the direct repeats occurred at a high frequency. Deletions occurred both when the direct repeats were in tandem and when they were separated by additional sequences. These deletions occurred during virus replication.

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Year:  1987        PMID： 3806800      PMCID： PMC254040     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  20 in total

1.  Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus.

Authors:  K Shimotohno; H M Temin
Journal:  Cell       Date:  1981-10       Impact factor: 41.582

2.  Spontaneous variation and synthesis in the U3 region of the long terminal repeat of an avian retrovirus.

Authors:  K Shimotohno; H M Temin
Journal:  J Virol       Date:  1982-01       Impact factor: 5.103

3.  High-frequency deletion in recovered retrovirus vectors containing exogenous DNA with promoters.

Authors:  M Emerman; H M Temin
Journal:  J Virol       Date:  1984-04       Impact factor: 5.103

4.  Expression of complete chicken thymidine kinase gene inserted in a retrovirus vector.

Authors:  P K Bandyopadhyay; H M Temin
Journal:  Mol Cell Biol       Date:  1984-04       Impact factor: 4.272

5.  High spontaneous mutation rate of Rous sarcoma virus demonstrated by direct sequencing of the RNA genome.

Authors:  J L Darlix; P F Spahr
Journal:  Nucleic Acids Res       Date:  1983-09-10       Impact factor: 16.971

6.  Involvement of directly repeated sequences in the generation of deletions of the avian sarcoma virus src gene.

Authors:  C A Omer; K Pogue-Geile; R Guntaka; K A Staskus; A J Faras
Journal:  J Virol       Date:  1983-08       Impact factor: 5.103

7.  Rearrangement and mutagenesis of a shuttle vector plasmid after passage in mammalian cells.

Authors:  A Razzaque; H Mizusawa; M M Seidman
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

8.  High mutation frequency in DNA transfected into mammalian cells.

Authors:  M P Calos; J S Lebkowski; M R Botchan
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

9.  High mutation rate of a spleen necrosis virus-based retrovirus vector.

Authors:  J P Dougherty; H M Temin
Journal:  Mol Cell Biol       Date:  1986-12       Impact factor: 4.272

10.  Retrovirus transduction: generation of infectious retroviruses expressing dominant and selectable genes is associated with in vivo recombination and deletion events.

Authors:  A L Joyner; A Bernstein
Journal:  Mol Cell Biol       Date:  1983-12       Impact factor: 4.272
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  32 in total

1.  Altering the intracellular environment increases the frequency of tandem repeat deletion during Moloney murine leukemia virus reverse transcription.

Authors:  J K Pfeiffer; R S Topping; N H Shin; A Telesnitsky
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

2.  Development of murine leukemia virus-based self-activating vectors that efficiently delete the selectable drug resistance gene during reverse transcription.

Authors:  K A Delviks; V K Pathak
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

3.  Effects of limiting homology at the site of intermolecular recombinogenic template switching during Moloney murine leukemia virus replication.

Authors:  J K Pfeiffer; A Telesnitsky
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

4.  Duck hepatitis B virus can tolerate insertion, deletion, and partial frameshift mutation in the distal pre-S region.

Authors:  J S Li; L Cova; R Buckland; V Lambert; G Deléage; C Trépo
Journal:  J Virol       Date:  1989-11       Impact factor: 5.103

5.  Replication of Mus dunni endogenous retrovirus depends on promoter activation followed by enhancer multimerization.

Authors:  G Wolgamot; A D Miller
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

Review 6.  Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation.

Authors:  H M Temin
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205

Review 7.  The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors.

Authors:  David W Emery
Journal:  Hum Gene Ther       Date:  2011-03-25       Impact factor: 5.695

8.  Relative rates of retroviral reverse transcriptase template switching during RNA- and DNA-dependent DNA synthesis.

Authors:  R R Bowman; W S Hu; V K Pathak
Journal:  J Virol       Date:  1998-06       Impact factor: 5.103

9.  E- vectors: development of novel self-inactivating and self-activating retroviral vectors for safer gene therapy.

Authors:  J G Julias; D Hash; V K Pathak
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

10.  Transforming variants of the avian myc-containing retrovirus FH3 arise prior to phenotypic selection.

Authors:  A T Tikhonenko; M L Linial
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103
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