Literature DB >> 7688465

Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation.

H M Temin1.   

Abstract

Human immunodeficiency virus variation is extensive and is based on numerous mistakes in reverse transcription. All retrovirus replication requires two strand transfers (growing point jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse transcription are the result of this requirement for the two strand transfers needed to form the provirus.

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Year:  1993        PMID： 7688465      PMCID： PMC47042          DOI： 10.1073/pnas.90.15.6900

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  35 in total

1.  Mechanism of transduction by retroviruses.

Authors:  A Swain; J M Coffin
Journal:  Science       Date:  1992-02-14       Impact factor: 47.728

2.  HIV mutation rate.

Authors:  M Nowak
Journal:  Nature       Date:  1990-10-11       Impact factor: 49.962

Review 3.  Frameshift mutation: determinants of specificity.

Authors:  L S Ripley
Journal:  Annu Rev Genet       Date:  1990       Impact factor: 16.830

Review 4.  Sex and recombination in retroviruses.

Authors:  H M Temin
Journal:  Trends Genet       Date:  1991-03       Impact factor: 11.639

5.  Effect of gamma radiation on retroviral recombination.

Authors:  W S Hu; H M Temin
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

6.  Characterization of large deletions occurring during a single round of retrovirus vector replication: novel deletion mechanism involving errors in strand transfer.

Authors:  G A Pulsinelli; H M Temin
Journal:  J Virol       Date:  1991-09       Impact factor: 5.103

7.  Abortive reverse transcription by mutants of Moloney murine leukemia virus deficient in the reverse transcriptase-associated RNase H function.

Authors:  N Tanese; A Telesnitsky; S P Goff
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

8.  Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions.

Authors:  V K Pathak; H M Temin
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

9.  Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase.

Authors:  J J DeStefano; L M Mallaber; L Rodriguez-Rodriguez; P J Fay; R A Bambara
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103

10.  Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.

Authors:  J A Peliska; S J Benkovic
Journal:  Science       Date:  1992-11-13       Impact factor: 47.728
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  129 in total

1.  Effect of distance between homologous sequences and 3' homology on the frequency of retroviral reverse transcriptase template switching.

Authors:  K A Delviks; V K Pathak
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

2.  Altering the intracellular environment increases the frequency of tandem repeat deletion during Moloney murine leukemia virus reverse transcription.

Authors:  J K Pfeiffer; R S Topping; N H Shin; A Telesnitsky
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

3.  Copy-choice recombination by reverse transcriptases: reshuffling of genetic markers mediated by RNA chaperones.

Authors:  M Negroni; H Buc
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

4.  Structural determinants of murine leukemia virus reverse transcriptase that affect the frequency of template switching.

Authors:  E S Svarovskaia; K A Delviks; C K Hwang; V K Pathak
Journal:  J Virol       Date:  2000-08       Impact factor: 5.103

5.  Effects of limiting homology at the site of intermolecular recombinogenic template switching during Moloney murine leukemia virus replication.

Authors:  J K Pfeiffer; A Telesnitsky
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

6.  The HIV-1 repeated sequence R as a robust hot-spot for copy-choice recombination.

Authors:  A Moumen; L Polomack; B Roques; H Buc; M Negroni
Journal:  Nucleic Acids Res       Date:  2001-09-15       Impact factor: 16.971

7.  Genomic stability of murine leukemia viruses containing insertions at the Env-3' untranslated region boundary.

Authors:  C R Logg; A Logg; C K Tai; P M Cannon; N Kasahara
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

8.  RNase H activity is required for high-frequency repeat deletion during Moloney murine leukemia virus replication.

Authors:  Jennifer L Brincat; Julie K Pfeiffer; Alice Telesnitsky
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

9.  Dynamic copy choice: steady state between murine leukemia virus polymerase and polymerase-dependent RNase H activity determines frequency of in vivo template switching.

Authors:  C K Hwang; E S Svarovskaia; V K Pathak
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-02       Impact factor: 11.205

10.  Mechanism analysis indicates that recombination events in HIV-1 initiate and complete over short distances, explaining why recombination frequencies are similar in different sections of the genome.

Authors:  Sean T Rigby; April E Rose; Mark N Hanson; Robert A Bambara
Journal:  J Mol Biol       Date:  2009-02-20       Impact factor: 5.469
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