Literature DB >> 380465

Effect of clavulanic acid on the in vitro synergism between carbenicillin and gentamicin against Serratia marcescens.

T Sirisanthana, S A Lerner.   

Abstract

Clavulanic acid, a potent beta-lactamase inhibitor, reduced the minimum inhibitory concentrations of carbenicillin for 13 of 15 clinical isolates of Serratia marcescens by at least eightfold. The combination of clavulanic acid and carbenicillin also exhibited synergistic activity with gentamicin against 11 of 15 isolates tested, including 9 of 10 strains which were highly resistant to carbenicillin (minimum inhibitory concentration >/= 8,000 mug/ml) and had previously been found resistant to the synergistic activity between carbenicillin and gentamicin.

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Year:  1979        PMID： 380465      PMCID： PMC352723          DOI： 10.1128/AAC.15.4.630

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  In vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillin.

Authors:  R Wise; J M Andrews; K A Bedford
Journal:  Antimicrob Agents Chemother       Date:  1978-03       Impact factor: 5.191

2.  Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus.

Authors:  C Reading; M Cole
Journal:  Antimicrob Agents Chemother       Date:  1977-05       Impact factor: 5.191

3.  Comparison of methods for differentiating among Serratia marcescens isolated from clinical specimens.

Authors:  E Roemisch; F E Kocka
Journal:  Am J Clin Pathol       Date:  1976-07       Impact factor: 2.493

4.  In vitro activity of gentamicin, amikacin and netilmicin alone and in combination with carbenicillin against Serratia marcescens.

Authors:  S M Pogwizd; S A Lerner
Journal:  Antimicrob Agents Chemother       Date:  1976-12       Impact factor: 5.191

5.  Synergy of azlocillin and mezlocillin combined with aminoglycoside antibiotics and cephalosporins.

Authors:  H C Neu; K P Fu
Journal:  Antimicrob Agents Chemother       Date:  1978-05       Impact factor: 5.191

6.  Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.

Authors:  C H O'Callaghan; A Morris; S M Kirby; A H Shingler
Journal:  Antimicrob Agents Chemother       Date:  1972-04       Impact factor: 5.191

7.  Effect of clavulanic Acid on anaerobic bacteria resistant to Beta-lactam antibiotics.

Authors:  J Wüst; T D Wilkins
Journal:  Antimicrob Agents Chemother       Date:  1978-01       Impact factor: 5.191
  7 in total
  3 in total

1.  Effect of clavulanic acid on minimal inhibitory concentrations of 16 antimicrobial agents tested against Legionella pneumophila.

Authors:  D J Pohlod; L D Saravolatz; E L Quinn; M M Somerville
Journal:  Antimicrob Agents Chemother       Date:  1980-08       Impact factor: 5.191

2.  Clavulanic acid and penicillin treatment of Staphylococcus aureus renal infection in mice.

Authors:  M S Heerema; D M Musher; T W Williams
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191

3.  Clinical trial of the efficacy and safety of ticarcillin and clavulanic acid.

Authors:  G A Roselle; R Bode; B Hamilton; M Bibler; R Sullivan; R Douce; J L Staneck; W E Bullock
Journal:  Antimicrob Agents Chemother       Date:  1985-03       Impact factor: 5.191
  3 in total

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