Literature DB >> 3801876

Anterior thalamus and substantia nigra: two distinct structures mediating experimental generalized seizures.

M A Mirski, A C McKeon, J A Ferrendelli.   

Abstract

Injection of gamma-vinyl aminobutyric acid (GVG) into the anterior thalamus protected rats against pentylenetetrazol (PTZ) seizures but not against maximal electroshock (MES) seizures. Injection of GVG into the substantia nigra protected against MES seizures but not against PTZ seizures. Both types of seizures were prevented by injections into both of the above brain regions. These data indicate that separate neuronal circuits mediate PTZ and MES seizures.

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Year:  1986        PMID: 3801876     DOI: 10.1016/0006-8993(86)90642-6

Source DB:  PubMed          Journal:  Brain Res        ISSN: 0006-8993            Impact factor:   3.252


  8 in total

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  8 in total

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