Literature DB >> 3801780

An examination of 5-hydroxytryptamine receptors in human saphenous vein.

J R Docherty, L Hyland.   

Abstract

We have examined the effects of antagonists on the isometric contraction of the human saphenous vein produced by 5-hydroxytryptamine (5-HT). The 5-HT2-antagonist ketanserin (1 microM) had little effect on the lower part of the concentration-response curve to 5-HT, but markedly shifted the upper part of the curve. Yohimbine caused an approximately parallel shift of the concentration-response curve to 5-HT, with a pA2 of 5.48, much lower than its pA2 against noradrenaline in the absence (6.36) or presence (7.06) of cocaine. It is concluded that there are two components to the contractile response to 5-HT in human saphenous vein: at low concentrations 5-HT activates a yohimbine-sensitive receptor, and at higher concentrations 5-HT activates a 5-HT2-receptor.

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Year:  1986        PMID： 3801780      PMCID： PMC1917039          DOI： 10.1111/j.1476-5381.1986.tb11122.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  15 in total

1.  Pre- and postsynaptic effects of yohimbine stereoisomers on noradrenergic transmission in the pulmonary artery of the rabbit.

Authors:  R Weitzell; T Tanaka; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-08       Impact factor: 3.000

2.  8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.

Authors:  D N Middlemiss; J R Fozard
Journal:  Eur J Pharmacol       Date:  1983-05-20       Impact factor: 4.432

Review 3.  Vascular serotonin receptors. Correlation with 5-HT1 and 5-HT2 binding sites.

Authors:  S J Peroutka
Journal:  Biochem Pharmacol       Date:  1984-08-01       Impact factor: 5.858

4.  Some quantitative uses of drug antagonists.

Authors:  O ARUNLAKSHANA; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1959-03

5.  Postsynaptic alpha-adrenoceptor subtypes in rabbit blood vessels and rat anococcygeus muscle studied in vitro.

Authors:  J R Docherty; K Starke
Journal:  J Cardiovasc Pharmacol       Date:  1981 Jul-Aug       Impact factor: 3.105

Review 6.  Serotonin (5HT) and its antagonists: involvement in the cardiovascular system.

Authors:  J F Marwood; G S Stokes
Journal:  Clin Exp Pharmacol Physiol       Date:  1984 Sep-Oct       Impact factor: 2.557

7.  Alpha-adrenoceptors, 5-hydroxytryptamine receptors and the action of dihydroergotamine in human venous preparations obtained during saphenectomy procedures for varicose veins.

Authors:  E Müller-Schweinitzer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-10       Impact factor: 3.000

8.  Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors.

Authors:  A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-06       Impact factor: 3.000

9.  Neuronal 5-HT receptors in the periphery.

Authors:  J R Fozard
Journal:  Neuropharmacology       Date:  1984-12       Impact factor: 5.250

10.  MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors.

Authors:  J R Fozard
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-05       Impact factor: 3.000
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  8 in total

1.  Contractions to 5-hydroxytryptamine in human coronary artery and human saphenous vein.

Authors:  M Borton; M Neligan; F Wood; P Dervan; K Goggins; J R Docherty
Journal:  Br J Clin Pharmacol       Date:  1990       Impact factor: 4.335

2.  Investigations of cardiovascular 5-hydroxytryptamine receptor subtypes in the rat.

Authors:  J R Docherty
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-01       Impact factor: 3.000

3.  Vasoactive responses of a human cystic artery: adrenoceptor characterization.

Authors:  D G Wyse
Journal:  Br J Clin Pharmacol       Date:  1988-06       Impact factor: 4.335

4.  5-HT1-like receptors requiring functional cyclo-oxygenase and 5-HT2 receptors independent of cyclo-oxygenase mediate contraction of the human umbilical artery.

Authors:  S J MacLennan; M J Whittle; J C McGrath
Journal:  Br J Pharmacol       Date:  1989-07       Impact factor: 8.739

5.  5-Hydroxytryptamine-induced contractions of the human isolated saphenous vein: involvement of 5-HT2 and 5-HT1D-like receptors, and a comparison with grafted veins.

Authors:  W A Bax; D Van Heuven-Nolsen; E Bos; M L Simoons; P R Saxena
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-05       Impact factor: 3.000

6.  Heterogeneity of 5-HT receptor subtypes in isolated human femoral and saphenous veins.

Authors:  E Glusa; E Müller-Schweinitzer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-02       Impact factor: 3.000

7.  5-Hydroxytryptamine (5-HT) contracts the guinea-pig isolated iliac artery via 5-HT1-like and 5-HT2 receptors.

Authors:  H Pertz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-12       Impact factor: 3.000

8.  The actions of 5-hydroxytryptamine receptor agonists and antagonists at pre- and postjunctional level on the canine saphenous vein.

Authors:  M Q Paiva; M M Caramona; W Osswald
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-12       Impact factor: 3.000
  8 in total

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