Literature DB >> 3796964

Did template-directed nucleation precede molecular replication?

L E Orgel.   

Abstract

It is proposed that mononucleotides incorporated into the surfaces of microcrystals of inorganic phosphates such as hydroxyapatite can act as templates to assemble complementary mononucleotides from solution, and that the phosphate groups of the assembled nucleotides can facilitate nucleation of a second hydroxyapatite crystal. This would provide a mechanism of replication that is subject to natural selection. The possible role of a replicating system of this kind in the origins of life on the earth is discussed.

Entities:  

Keywords:  NASA Discipline Exobiology; Non-NASA Center

Mesh:

Substances:

Year:  1986        PMID: 3796964     DOI: 10.1007/bf01809810

Source DB:  PubMed          Journal:  Orig Life Evol Biosph        ISSN: 0169-6149            Impact factor:   1.950


  9 in total

1.  Template-directed synthesis of novel, nucleic acid-like structures.

Authors:  A W Schwartz; L E Orgel
Journal:  Science       Date:  1985-05-03       Impact factor: 47.728

2.  Transphosphorylation from nucleoside Di- and triphosphates by apatite crystals.

Authors:  S M KRANE; M J GLIMCHER
Journal:  J Biol Chem       Date:  1962-09       Impact factor: 5.157

3.  Precipitation of phosphates in a primeval sea.

Authors:  D McConnell; G J Handschuh; L E Orgel
Journal:  Science       Date:  1973-08-10       Impact factor: 47.728

4.  The role of synthetic and bone extracted Ca-phospholipid-PO4 complexes in hydroxyapatite formation.

Authors:  A L Boskey; A S Posner
Journal:  Calcif Tissue Res       Date:  1977-10-20

5.  Non-enzymic template-directed synthesis on RNA random copolymers. Poly(C, G) templates.

Authors:  G F Joyce; L E Orgel
Journal:  J Mol Biol       Date:  1986-04-05       Impact factor: 5.469

6.  Chiral versus chemical evolutions and the appearance of life.

Authors:  G Spach
Journal:  Orig Life       Date:  1984

7.  Chiral selection in poly(C)-directed synthesis of oligo(G).

Authors:  G F Joyce; G M Visser; C A van Boeckel; J H van Boom; L E Orgel; J van Westrenen
Journal:  Nature       Date:  1984 Aug 16-22       Impact factor: 49.962

8.  Oligonucleotide formation catalyzed by mononucleotide matrices.

Authors:  R Lohrmann
Journal:  J Mol Evol       Date:  1982       Impact factor: 2.395

9.  Template-directed synthesis and selective adsorption of oligoadenylates on hydroxyapatite.

Authors:  D Gibbs; R Lohrmann; L E Orgel
Journal:  J Mol Evol       Date:  1980-08       Impact factor: 2.395

  9 in total
  10 in total

1.  Polyphosphorylation and non-enzymatic template-directed ligation of oligonucleotides.

Authors:  K Gao; L E Orgel
Journal:  Orig Life Evol Biosph       Date:  2000-02       Impact factor: 1.950

Review 2.  The RNA World: molecular cooperation at the origins of life.

Authors:  Paul G Higgs; Niles Lehman
Journal:  Nat Rev Genet       Date:  2014-11-11       Impact factor: 53.242

3.  Alfonso Luis Herrera and the Beginnings of Evolutionism and Studies in the Origin of Life in Mexico.

Authors:  Ismael Ledesma-Mateos; H James Cleaves
Journal:  J Mol Evol       Date:  2016-12-02       Impact factor: 2.395

Review 4.  Before enzymes and templates: theory of surface metabolism.

Authors:  G Wächtershäuser
Journal:  Microbiol Rev       Date:  1988-12

5.  The case for an ancestral genetic system involving simple analogues of the nucleotides.

Authors:  G F Joyce; A W Schwartz; S L Miller; L E Orgel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

6.  An all-purine precursor of nucleic acids.

Authors:  G Wächtershäuser
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

7.  Primeval procreative comet pond.

Authors:  B C Clark
Journal:  Orig Life Evol Biosph       Date:  1988       Impact factor: 1.950

8.  Prebiotic cytosine synthesis: a critical analysis and implications for the origin of life.

Authors:  R Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-13       Impact factor: 11.205

9.  The prebiotic role of adenine: a critical analysis.

Authors:  R Shapiro
Journal:  Orig Life Evol Biosph       Date:  1995-06       Impact factor: 1.950

10.  Thermodynamic and Kinetic Sequence Selection in Enzyme-Free Polymer Self-Assembly inside a Non-equilibrium RNA Reactor.

Authors:  Tobias Göppel; Joachim H Rosenberger; Bernhard Altaner; Ulrich Gerland
Journal:  Life (Basel)       Date:  2022-04-10
  10 in total

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