Literature DB >> 3791563

Synthesis and antitumor activity of a platinum (II)-doxorubicin complex.

F Zunino, G Savi, A Pasini.   

Abstract

A mixed platinum (II) complex with tert-butylamine and doxorubicin (coordinated via the amino-group) has been synthesized and tested for antitumor activity. The results indicate that the complex was active against doxorubicin-resistant P388 and cisplatin-resistant L1210 leukemias, while maintaining antitumor activity against sensitive parent lines.

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Year:  1986        PMID： 3791563     DOI： 10.1007/bf00262293

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  5 in total

1.  Molecular structural effects involved in the interaction of anthracyclines with DNA.

Authors:  F Zunino; A Di Marco; A Zaccara
Journal:  Chem Biol Interact       Date:  1979-02       Impact factor: 5.192

2.  Adriamycin and cis-platinum in advanced ovarian cancer.

Authors:  A de Gramont; Y Drolet; A Lavoie; M Painchaud; R Blouin; C Tessier; P Ouellet
Journal:  Eur J Cancer Clin Oncol       Date:  1985-06

3.  High-dose adriamycin (ADM) and cis-platinum (DDP) in advanced soft-tissue sarcomas and invasive thymomas. A pilot study.

Authors:  T H Klippstein; P S Mitrou; K J Kochendörfer; L Bergmann
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

4.  2,4-Diamino-6-(bis-2-chloroethyl)aminomethyl pteridine. A new potent anticancer drug.

Authors:  M A Khaled; R D Morin; F Benington; J P Daugherty
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

5.  Cellular pharmacology of 3'-(4-morpholinyl) and 3'-(4-methoxy-1-piperidinyl) derivatives of 3'-deaminodaunorubicin in human colon carcinoma cells in vitro.

Authors:  J B Johnston; R I Glazer
Journal:  Cancer Res       Date:  1983-04       Impact factor: 12.701
  5 in total
  2 in total

1.  Evaluation of a platinum-doxorubicin complex in experimental tumor systems.

Authors:  F Zunino; G Pratesi; F Formelli; A Pasini
Journal:  Invest New Drugs       Date:  1990-11       Impact factor: 3.850

2.  The interaction of DNA-targeted platinum phenanthridinium complexes with DNA.

Authors:  J Whittaker; W D McFadyen; G Wickham; L P Wakelin; V Murray
Journal:  Nucleic Acids Res       Date:  1998-09-01       Impact factor: 16.971
  2 in total

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