Literature DB >> 3789266

Leishmania major: antileishmanial activity of methylbenzethonium chloride.

J El-On, G Messer.   

Abstract

Methylbenzethonium chloride (MBCl) decreased the growth of Leishmania major promastigotes and amastigotes in vitro. This decrease occurred during 4 days of exposure to the drug at concentrations of 0.1 to 2.5 micrograms ml-1. MBCl at 2 micrograms ml-1 killed almost 100% of the free living promastigotes and 87% of amastigotes within 4 days of treatment. Electron microscopy studies showed marked swelling of mitochondria in treated parasites. A possible additional effect on the parasite surface membrane is discussed.

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Year:  1986        PMID： 3789266     DOI： 10.4269/ajtmh.1986.35.1110

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  7 in total

1.  Identification of specific pluripotent stem cell death--inducing small molecules by chemical screening.

Authors:  Celia Conesa; Michael Xavier Doss; Charles Antzelevitch; Agapios Sachinidis; Javier Sancho; José Alberto Carrodeguas
Journal:  Stem Cell Rev Rep       Date:  2012-03       Impact factor: 5.739

2.  Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania.

Authors:  M Chen; S B Christensen; J Blom; E Lemmich; L Nadelmann; K Fich; T G Theander; A Kharazmi
Journal:  Antimicrob Agents Chemother       Date:  1993-12       Impact factor: 5.191

3.  Berberine derivatives as antileishmanial drugs.

Authors:  J L Vennerstrom; J K Lovelace; V B Waits; W L Hanson; D L Klayman
Journal:  Antimicrob Agents Chemother       Date:  1990-05       Impact factor: 5.191

4.  Leishmania infections damage the feeding mechanism of the sandfly vector and implement parasite transmission by bite.

Authors:  Y Schlein; R L Jacobson; G Messer
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

5.  Leishmania resistant to sodium stibogluconate: drug-associated macrophage-dependent killing.

Authors:  M E Ibrahim; M Hag-Ali; A M el-Hassan; T G Theander; A Kharazmi
Journal:  Parasitol Res       Date:  1994       Impact factor: 2.289

Review 6.  Potential Challenges of Controlling Leishmaniasis in Sri Lanka at a Disease Outbreak.

Authors:  Tharaka Wijerathna; Nayana Gunathilaka; Kithsiri Gunawardana; Wasana Rodrigo
Journal:  Biomed Res Int       Date:  2017-05-28       Impact factor: 3.411

7.  Is paromomycin an effective and safe treatment against cutaneous leishmaniasis? A meta-analysis of 14 randomized controlled trials.

Authors:  Dae Hyun Kim; Hye Jin Chung; Joachim Bleys; Reza F Ghohestani
Journal:  PLoS Negl Trop Dis       Date:  2009-02-17
  7 in total

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