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Literature DB >> 2360830

Berberine derivatives as antileishmanial drugs.

J L Vennerstrom¹, J K Lovelace, V B Waits, W L Hanson, D L Klayman.

Abstract

Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not as potent as meglumine antimonate (Glucantime), a standard drug for the treatment of leishmaniasis. Only berberine and 8-cyanodihydroberberine showed significant activity (greater than 50% suppression of lesion size) against L. braziliensis panamensis.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1990 PMID： 2360830 PMCID： PMC171721 DOI： 10.1128/AAC.34.5.918

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

5 in total

1. Effect of berberine chloride on Leishmania donovani.

Authors: A K Ghosh; M M Rakshit; D K Ghosh
Journal: Indian J Med Res Date: 1983-09 Impact factor: 2.375

2. Testing of drugs for antileishmanial activity in golden hamsters infected with Leishmania donovani.

Authors: W L Hanson; W L Chapman; K E Kinnamon
Journal: Int J Parasitol Date: 1977-12 Impact factor: 3.981

3. Leishmania major: antileishmanial activity of methylbenzethonium chloride.

Authors: J El-On; G Messer
Journal: Am J Trop Med Hyg Date: 1986-11 Impact factor: 2.345

4. Protoberberine alkaloids as antimalarials.

Authors: J L Vennerstrom; D L Klayman
Journal: J Med Chem Date: 1988-06 Impact factor: 7.446

5. Leishmania donovani: amastigote inhibition and mode of action of berberine.

Authors: A K Ghosh; F K Bhattacharyya; D K Ghosh
Journal: Exp Parasitol Date: 1985-12 Impact factor: 2.011

5 in total

21 in total

Review 1. Natural products as antiparasitic drugs.

Authors: O Kayser; A F Kiderlen; S L Croft
Journal: Parasitol Res Date: 2003-02-20 Impact factor: 2.289

2. Fabrication, characterization and optimization of berberine-loaded PLA nanoparticles using coaxial electrospray for sustained drug release.

Authors: Reza Ghaffarzadegan; Sepideh Khoee; Shamsali Rezazadeh
Journal: Daru Date: 2020-04-20 Impact factor: 3.117

Review 3. Liposomal drug delivery systems for the treatment of leishmaniasis.

Authors: Felipe Francisco Tuon; Leticia Ramos Dantas; Regina Maia de Souza; Victoria Stadler Tasca Ribeiro; Valdir Sabbaga Amato
Journal: Parasitol Res Date: 2022-09-16 Impact factor: 2.383

4. Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania.

Authors: M Chen; S B Christensen; J Blom; E Lemmich; L Nadelmann; K Fich; T G Theander; A Kharazmi
Journal: Antimicrob Agents Chemother Date: 1993-12 Impact factor: 5.191

5. Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani.

Authors: M Chen; S B Christensen; T G Theander; A Kharazmi
Journal: Antimicrob Agents Chemother Date: 1994-06 Impact factor: 5.191

Berberine derivatives as antileishmanial drugs.

1. Effect of berberine chloride on Leishmania donovani.

2. Testing of drugs for antileishmanial activity in golden hamsters infected with Leishmania donovani.

3. Leishmania major: antileishmanial activity of methylbenzethonium chloride.

4. Protoberberine alkaloids as antimalarials.

5. Leishmania donovani: amastigote inhibition and mode of action of berberine.

Review 1. Natural products as antiparasitic drugs.

2. Fabrication, characterization and optimization of berberine-loaded PLA nanoparticles using coaxial electrospray for sustained drug release.

Review 3. Liposomal drug delivery systems for the treatment of leishmaniasis.

4. Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania.

5. Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani.

6. Antileishmanial Activities of Greek Juniper (Juniperus excelsa M.Bieb.) Against Leishmania major Promastigotes.

7. Weak C-H···X (X = O, N) hydrogen bonds in the crystal structure of dihydroberberine.

Review 8. Emerging therapeutic targets for treatment of leishmaniasis.

9. Antileishmanial constituents of the Panamanian endophytic fungus Edenia sp.

10. Synthesis of N-Mannich bases of berberine linking piperazine moieties revealing anticancer and antioxidant effects.