Literature DB >> 6254991

Comparison of the cleavage of pyrimidine dimers by the bacteriophage T4 and Micrococcus luteus UV-specific endonucleases.

L K Gordon, W A Haseltine.   

Abstract

A comparison was made of the activity of the UV-specific endonucleases of bacteriophage T4 (T4 endonuclease V) and of Micrococcus luteus on ultravilet light-irradiated DNA substrates of defined sequence. The two enzymes cleave DNA at the site of pyrimidine dimers with the same frequency. The products of the cleavage reaction are the same, suggesting that the scission of DNA by T4 endonuclease V occurs via the combined actin of a pyrimidine dimer specific DNA glycosylase and an apyrimidinic-apurinic (AP) endonuclease as was recently shown for the M. luteus enzyme. The pyrimidine dimer DNA-glycosylase activity of both enzymes is more active on double-stranded DNA than it is on single-stranded DNA.

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Year:  1980        PMID： 6254991

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  40 in total

1.  Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin.

Authors:  F Carrier; P T Georgel; P Pourquier; M Blake; H U Kontny; M J Antinore; M Gariboldi; T G Myers; J N Weinstein; Y Pommier; A J Fornace
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

2.  9-[(10-(aden-9-yl)-4,8-diazadecyl)amino]-6-chloro-2-methoxy-acridine incises DNA at apurinic sites.

Authors:  J F Constant; T R O'Connor; J Lhomme; J Laval
Journal:  Nucleic Acids Res       Date:  1988-03-25       Impact factor: 16.971

3.  Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicase.

Authors:  Nadine Mathieu; Nina Kaczmarek; Hanspeter Naegeli
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-27       Impact factor: 11.205

4.  Characterization and genetic mapping of a mutation affecting apurinic endonuclease activity in Staphylococcus aureus.

Authors:  J E Tam; P A Pattee
Journal:  J Bacteriol       Date:  1986-11       Impact factor: 3.490

5.  T4 DNA polymerase (3'-5') exonuclease, an enzyme for the detection and quantitation of stable DNA lesions: the ultraviolet light example.

Authors:  P W Doetsch; G L Chan; W A Haseltine
Journal:  Nucleic Acids Res       Date:  1985-05-10       Impact factor: 16.971

6.  The DNA sequence specificity of bleomycin cleavage in a systematically altered DNA sequence.

Authors:  Shweta D Gautam; Jon K Chen; Vincent Murray
Journal:  J Biol Inorg Chem       Date:  2017-05-16       Impact factor: 3.358

7.  Binding of transcription factors creates hot spots for UV photoproducts in vivo.

Authors:  G P Pfeifer; R Drouin; A D Riggs; G P Holmquist
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

8.  Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites.

Authors:  T R O'Connor; J Laval
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

9.  UV-induced photoproducts of 5-methylcytosine in a DNA sequence context.

Authors:  T Barna; J Malinowski; P Holton; M Ruchirawat; F F Becker; J N Lapeyre
Journal:  Nucleic Acids Res       Date:  1988-04-25       Impact factor: 16.971

10.  Partial complementation of the UV sensitivity of E. coli and yeast excision repair mutants by the cloned denV gene of bacteriophage T4.

Authors:  J M Chenevert; L Naumovski; R A Schultz; E C Friedberg
Journal:  Mol Gen Genet       Date:  1986-04
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