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Literature DB >> 3783448

A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics.

Abstract

A dispersion model of hepatic elimination is presented to describe metabolite formation and elimination kinetics within the liver, consistent with the known physiology and biochemistry of this organ. The model is based on the spread in residence times of blood flowing through the liver. This dispersion model is shown to be more consistent with transient and steady-state data obtained after the single passage of phenacetin and acetaminophen through the liver (both normal and retrograde perfusions) than other models of hepatic elimination. The dispersion model is suitable for the evaluation of enzyme heterogeneity using experimentally obtained metabolite data.

Entities: Chemical

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Year: 1986 PMID： 3783448 DOI： 10.1007/bf01106708

Source DB: PubMed Journal: J Pharmacokinet Biopharm ISSN： 0090-466X

16 in total

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Authors: C A GORESKY
Journal: Am J Physiol Date: 1963-04

2. Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT.

Authors: P V Pedersen
Journal: J Pharmacokinet Biopharm Date: 1977-10

3. A dispersion model of hepatic elimination: 2. Steady-state considerations--influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity.

Authors: M S Roberts; M Rowland
Journal: J Pharmacokinet Biopharm Date: 1986-06

4. A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

Authors: M S Roberts; M Rowland
Journal: J Pharmacokinet Biopharm Date: 1986-06

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Authors: D L Miller; C S Zanolli; J J Gumucio
Journal: Gastroenterology Date: 1979-05 Impact factor: 22.682

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Authors: M Rowland; L Z Benet; G G Graham
Journal: J Pharmacokinet Biopharm Date: 1973-04

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Authors: J J Gumucio; D L Miller
Journal: Gastroenterology Date: 1981-02 Impact factor: 22.682

8. Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance.

Authors: K S Pang; M Rowland
Journal: J Pharmacokinet Biopharm Date: 1977-12

9. Retrograde perfusion to probe the heterogeneous distribution of hepatic drug metabolizing enzymes in rats.

Authors: K S Pang; J A Terrell
Journal: J Pharmacol Exp Ther Date: 1981-02 Impact factor: 4.030

10. Kinetics of metabolite formation and elimination in the perfused rat liver preparation: differences between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin.

Authors: K S Pang; J R Gillette
Journal: J Pharmacol Exp Ther Date: 1978-10 Impact factor: 4.030

16 in total

1. Modeling of hepatic elimination and organ distribution kinetics with the extended convection-dispersion model.

Authors: M S Roberts; Y G Anissimov
Journal: J Pharmacokinet Biopharm Date: 1999-08

2. Founding figures of pharmacokinetics: tribute to Malcolm Rowland.

Authors: Leon Aarons; Leslie Z Benet
Journal: J Pharmacokinet Pharmacodyn Date: 2010-12 Impact factor: 2.745

3. Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 1. Effect of changes in perfusate flow and albumin concentration on sucrose and taurocholate.

Authors: M S Roberts; S Fraser; A Wagner; L McLeod
Journal: J Pharmacokinet Biopharm Date: 1990-06

4. Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage.

Authors: Peng Li; Thomas A Robertson; Qian Zhang; Linda M Fletcher; Darrell H G Crawford; Michael Weiss; Michael S Roberts
Journal: Pharm Res Date: 2012-06 Impact factor: 4.200

5. Availability predictions by hepatic elimination models for Michaelis-Menten kinetics.

Authors: M S Roberts; J D Donaldson; D Jackett
Journal: J Pharmacokinet Biopharm Date: 1989-12

6. A comparative investigation of hepatic clearance models: predictions of metabolite formation and elimination.

Authors: M V St-Pierre; P I Lee; K S Pang
Journal: J Pharmacokinet Biopharm Date: 1992-04

7. Axial tissue diffusion can account for the disparity between current models of hepatic elimination for lipophilic drugs.

Authors: L P Rivory; M S Roberts; S M Pond
Journal: J Pharmacokinet Biopharm Date: 1992-02

Review 8. Modeling kinetics of subcellular disposition of chemicals.

Authors: Stefan Balaz
Journal: Chem Rev Date: 2009-05 Impact factor: 60.622

9. Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 2. Effect of pharmacological agents, retrograde perfusions, and enzyme inhibition on evans blue, sucrose, water, and taurocholate.

Authors: M S Roberts; S Fraser; A Wagner; L McLeod
Journal: J Pharmacokinet Biopharm Date: 1990-06

10. Application of the dispersion model for description of the outflow dilution profiles of noneliminated reference indicators in rat liver perfusion studies.

Authors: A J Schwab; W Geng; K S Pang
Journal: J Pharmacokinet Biopharm Date: 1998-04