Literature DB >> 2732724

Reduced inhibitory effects of clonidine and neuropeptide Y on 3H-noradrenaline release from synaptosomes of the medulla oblongata of the spontaneously hypertensive rat.

M Martire1, K Fuxe, G Pistritto, P Preziosi, L F Agnati.   

Abstract

The release of 3H-noradrenaline (3H-NA) evoked by high-K+ (15 mM) was studied in synaptosomes isolated from the medulla oblongata of the normotensive Wistar-Kyoto and spontaneously hypertensive male rat (14 weeks old) using a superfusion apparatus. Based on concentration-response curves clonidine was shown to have a reduced ability to inhibit 3H-NA release in synaptosomes isolated from the spontaneously hypertensive rat (SHR) versus the normotensive rat. Furthermore, only a high concentration of NPY (100 nM) had the ability to enhance the inhibitory effects of clonidine on 3H-NA release in synaptosomes isolated from the medulla oblongata of the SH male rat, while 1 nM of NPY was effective in synaptosomes isolated from the medulla oblongata of the normotensive Wistar-Kyoto rat. These results may indicate a reduced presynaptic alpha 2-adrenoceptor and NPY receptor function to inhibit 3H-NA release from NA and/or adrenaline (A) nerve terminals in the medulla oblongata of the adult 14 weeks old SHR.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2732724     DOI： 10.1007/bf01260503

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  23 in total

1.  Morphofunctional studies on the neuropeptide Y/adrenaline costoring terminal systems in the dorsal cardiovascular region of the medulla oblongata. Focus on receptor-receptor interactions in cotransmission.

Authors:  K Fuxe; L F Agnati; A Härfstrand; A M Janson; A Neumeyer; K Andersson; M Ruggeri; M Zoli; M Goldstein
Journal:  Prog Brain Res       Date:  1986       Impact factor: 2.453

2.  Studies on neuropeptide-Y catecholamine interactions in central cardiovascular regulation in the alpha-chloralose anaesthetized rat. Evidence for a possible new way of activating the alpha-2 adrenergic transmission line.

Authors:  A Härfstrand; K Fuxe; L F Agnati; D Ganten; P Eneroth; K Tatemoto; V Mutt
Journal:  Clin Exp Hypertens A       Date:  1984

3.  Evidence for a modulation by neuropeptide Y of the alpha-2 adrenergic transmission line in central adrenaline synapses. New possibilities for treatment of hypertensive disorders.

Authors:  K Fuxe; L F Agnati; A Härfstrand; M Martire; M Goldstein; R Grimaldi; P Bernardi; I Zini; K Tatemoto; V Mutt
Journal:  Clin Exp Hypertens A       Date:  1984

Review 4.  Presynaptic receptors.

Authors:  K Starke
Journal:  Annu Rev Pharmacol Toxicol       Date:  1981       Impact factor: 13.820

5.  Neuropeptide Y in vitro selectivity increases the number of alpha 2-adrenergic binding sites in membranes of the medulla oblongata of the rat.

Authors:  L F Agnati; K Fuxe; F Benfenati; N Battistini; A Härfstrand; K Tatemoto; T Hökfelt; V Mutt
Journal:  Acta Physiol Scand       Date:  1983-07

6.  Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function.

Authors:  J M Lundberg; L Terenius; T Hökfelt; C R Martling; K Tatemoto; V Mutt; J Polak; S Bloom; M Goldstein
Journal:  Acta Physiol Scand       Date:  1982-12

7.  A simple apparatus for studying the release of neurotransmitters from synaptosomes.

Authors:  M Raiteri; F Angelini; G Levi
Journal:  Eur J Pharmacol       Date:  1974-03       Impact factor: 4.432

8.  Studies on neuropeptide Y-catecholamine interactions in the hypothalamus and in the forebrain of the male rat. Relationship to neuroendocrine function.

Authors:  A Härfstrand; K Fuxe; L F Agnati; P Eneroth; I Zini; M Zoli; K Andersson; G von Euler; L Terenius; V Mutt; M Goldstein
Journal:  Neurochem Int       Date:  1986       Impact factor: 3.921

9.  Selective reduction of adrenaline turnover in the dorsal midline area of the caudal medulla oblongata and increase of hypothalamic adrenaline levels in the Lyon strain of genetically hypertensive rats.

Authors:  K Fuxe; M Vincent; K Andersson; A Härfstrand; L F Agnati; J Sassard; F Benfenati; T Hökfelt
Journal:  Eur J Pharmacol       Date:  1982-01-22       Impact factor: 4.432

10.  Neuropeptide Y (NPY) depresses the secretion of 3H-noradrenaline and the contractile response evoked by field stimulation, in rat vas deferens.

Authors:  J M Lundberg; L Stjarne
Journal:  Acta Physiol Scand       Date:  1984-03
View more
  1 in total

1.  Enhanced inhibitory control by neuropeptide Y Y5 receptor blockade in rats.

Authors:  A Bari; A Dec; A W Lee; J Lee; D Song; E Dale; J Peterson; S Zorn; X Huang; B Campbell; T W Robbins; A R West
Journal:  Psychopharmacology (Berl)       Date:  2014-09-07       Impact factor: 4.530
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.