Literature DB >> 3770019

'In vitro' metabolism of N-picolyl-3,5-dimethylbenzamides.

O Caputo, F Viola, G Grosa, F Rocco, G Biglino.   

Abstract

'In vitro' metabolism of three isomeric N-picolyl-3,5-dimethylbenzamides was studied. The metabolites were isolated through TLC and HPLC techniques and identified by direct comparison with authentic compounds. The results of phenobarbital and 3-methyl-cholantrene inductions are given.

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Year:  1986        PMID： 3770019     DOI： 10.1007/BF03189833

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  6 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Semisynthetic coumermycins. II. Preparation and properties of 3-(substituted benzamido)-4-hydroxy-8-methyl-7-[3-O-(5-methyl-2-pyrrolylcarbonyl)noviosyloxy] coumarins.

Authors:  H Schmitz; R L DeVault; C D McDonnell; J C Godfrey
Journal:  J Antibiot (Tokyo)       Date:  1968-10       Impact factor: 2.649

3.  [Microbiological oxidation of mesitylene].

Authors:  L A Golovleva; Kh G Ganbarov; V M Adanin; V G Sakharovskiĭ; G K Skriabin
Journal:  Dokl Akad Nauk SSSR       Date:  1977-05-21

4.  [Comparative study of the pharmacological activity of N-(4-picolyl)-3,5-dimethylbenzamide (M-14012-4) and its N-oxide metabolite (M-3312-4). New pharmacological aspects].

Authors:  L Casais; A Colom; M P Martín del Río; M Vallejo; E Cuenca
Journal:  Arch Farmacol Toxicol       Date:  1979-12

5.  Medicinal chemistry of 3.5-dimethylbenzoic acid, I: N-picolyl-amides.

Authors:  M F Braña; J M Castellano; C M Roldán; F P Rabadán
Journal:  Arch Farmacol Toxicol       Date:  1978-08

6.  Metabolism and kinetics of renal elimination of N-picolyl-3,5-dimethylbenzamides.

Authors:  P D García de Jalón; E González Fernández; A Idoipe; M R Martínez Larrañaga; M F Braña
Journal:  Arzneimittelforschung       Date:  1979
  6 in total
  1 in total

1.  Study of the disposition kinetics of the N-oxide-derivative: a metabolite of picobenzide.

Authors:  D Santos Buelga; E L Mariño; A Domínguez-Gil
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1989 Jan-Mar       Impact factor: 2.441
  1 in total

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