Literature DB >> 2759130

Study of the disposition kinetics of the N-oxide-derivative: a metabolite of picobenzide.

D Santos Buelga1, E L Mariño, A Domínguez-Gil.   

Abstract

The disposition kinetics of the N-oxide of picobenzide were studied after administration to rabbits at a bolus dose of 30 mg/kg of picobenzide intravenously. The biotransformation process fits a first-order kinetic process, and the metabolite shows good access capacity to the peripheral compartment. The N-oxide of picobenzide was determined by D.P.P. and parametric estimation was performed by the SIMPLEX method as the search algorithm.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2759130     DOI： 10.1007/BF03190837

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  8 in total

1.  [Pharmacokinetic parameters in relation to structure of the N-pycolyl-3,5-dimethylbenzamides (author's transl)].

Authors:  A Idoipe Tomás
Journal:  Arch Farmacol Toxicol       Date:  1977-08

2.  Pharmacokinetics and initial distribution of a new neuroleptic agent picobenzide (M-14012-4).

Authors:  M V Calvo; M A Nalda; J M Lanao; A Dominguez-Gil; S Carrasco
Journal:  Int J Clin Pharmacol Ther Toxicol       Date:  1985-05

3.  [Pharmacokinetic study of the picobenzide endovenously administered (author's transl)].

Authors:  A González González; P Ayllón Rojas; F Sanz Fernández; D Rodríguez Devesa; C Martínez Roldán
Journal:  Arch Farmacol Toxicol       Date:  1980-08

4.  Determination of N-oxide of picobenzide by differential pulse polarography.

Authors:  D Santos Buelga; E L Mariño; A Dominguez-Gil; A Sanchen Perez
Journal:  Farmaco Prat       Date:  1983-10

5.  Medicinal chemistry of 3.5-dimethylbenzoic acid, I: N-picolyl-amides.

Authors:  M F Braña; J M Castellano; C M Roldán; F P Rabadán
Journal:  Arch Farmacol Toxicol       Date:  1978-08

6.  Metabolism and kinetics of renal elimination of N-picolyl-3,5-dimethylbenzamides.

Authors:  P D García de Jalón; E González Fernández; A Idoipe; M R Martínez Larrañaga; M F Braña
Journal:  Arzneimittelforschung       Date:  1979

7.  'In vitro' metabolism of N-picolyl-3,5-dimethylbenzamides.

Authors:  O Caputo; F Viola; G Grosa; F Rocco; G Biglino
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1986 Apr-Jun       Impact factor: 2.441

8.  Isolation and identification of the N-oxide metabolite of picobenzide in human urine.

Authors:  M J Nieto; J M Hernandez Hernandez; J M Lanao; C Fernández; A Domínguez-Gil
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1986 Jan-Mar       Impact factor: 2.441
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.