| Literature DB >> 3762316 |
Abstract
The effects of capsaicin on stress ulcer formation, plasma corticosterone levels and gastric acid secretion were examined in rats. Capsaicin desensitization did not affect restraint stress ulcer formation but was associated with markedly elevated corticosterone levels, even in non-stressed rats. Acute, orally administered capsaicin augmented ulcer formation only if its administration was followed immediately by restraint stress. Delays of 1, 2, or 3 h between drug administration and stress produced ulceration comparable to control values. Capsaicin did not affect basal (non-stimulated) gastric acid secretion but substantially decreased pentagastrin-stimulated acid output.Entities:
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Year: 1986 PMID： 3762316 DOI： 10.1016/0024-3205(86)90383-8
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037