| Literature DB >> 3760140 |
M H Snyder, M L Clements, D Herrington, W T London, E L Tierney, B R Murphy.
Abstract
We evaluated the abilities of three different avian influenza A viruses to attenuate the wild-type human influenza A/Korea/1/82 (H3N2) virus in squirrel monkeys, chimpanzees, and adult seronegative human volunteers. Two of these, avian influenza A/Mallard/NY/78 and A/Mallard/Alberta/76 viruses, appeared to be satisfactory donors of attenuating genes for the production of live influenza A reassortant virus vaccines for human use because the reassortants exhibited an acceptable balance between attenuation and immunogenicity.Entities:
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Year: 1986 PMID: 3760140 PMCID: PMC268939 DOI: 10.1128/jcm.24.3.467-469.1986
Source DB: PubMed Journal: J Clin Microbiol ISSN: 0095-1137 Impact factor: 5.948