Literature DB >> 2913033

Comparison of the virologic and immunologic responses of volunteers to live avian-human influenza A H3N2 reassortant virus vaccines derived from two different avian influenza virus donors.

M L Clements1, S D Sears, K Christina, B R Murphy, M H Snyder.   

Abstract

We compared the abilities of the six internal RNA segments of two avian influenza viruses, A/Mallard/Alberta/88/76 (H3N8) and A/Mallard/NY/6750/78 (H2N2), to confer attenuation on wild-type human influenza A/Bethesda/1/85 (H3N2) virus in seronegative adult volunteers. Live avian-human influenza A reassortant virus vaccines derived from either avian virus parent were comparable in the following properties: safety, infectivity, immunogenicity, and genetic stability. Since the avian influenza A/Mallard/Alberta/76 virus offered no clear advantage as a donor virus, we will conduct our future evaluations on live influenza A virus reassortants derived from the more extensively characterized avian influenza A/Mallard/NY/78 virus.

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Year:  1989        PMID： 2913033      PMCID： PMC267272          DOI： 10.1128/jcm.27.1.219-222.1989

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  9 in total

1.  Dose response of influenza A/Washington/897/80 (H3N2) avian-human reassortant virus in adult volunteers.

Authors:  B R Murphy; M L Clements; E L Tierney; R E Black; J Stienberg; R M Chanock
Journal:  J Infect Dis       Date:  1985-07       Impact factor: 5.226

2.  Temperature-sensitive mutants of influenza virus. II. Attenuation of ts recombinants for man.

Authors:  B R Murphy; E G Chalhub; S R Nusinoff; R M Chanock
Journal:  J Infect Dis       Date:  1972-08       Impact factor: 5.226

3.  Comparison by studies in squirrel monkeys, chimpanzees, and adult humans of avian-human influenza A virus reassortants derived from different avian influenza virus donors.

Authors:  M H Snyder; M L Clements; D Herrington; W T London; E L Tierney; B R Murphy
Journal:  J Clin Microbiol       Date:  1986-09       Impact factor: 5.948

4.  Determination of antibody response to influenza virus surface glycoproteins by kinetic enzyme-linked immunosorbent assay.

Authors:  M H Snyder; S Banks; B R Murphy
Journal:  J Clin Microbiol       Date:  1988-10       Impact factor: 5.948

5.  Temperature-sensitive mutants of influenza virus. 3. Further characterization of the ts-1(E) influenza A recombinant (H3N2) virus in man.

Authors:  B R Murphy; E G Chalhub; S R Nusinoff; J Kasel; R M Chanock
Journal:  J Infect Dis       Date:  1973-10       Impact factor: 5.226

6.  Avian-human reassortant influenza A viruses derived by mating avian and human influenza A viruses.

Authors:  B R Murphy; A J Buckler-White; W T London; J Harper; E L Tierney; N T Miller; L J Reck; R M Chanock; V S Hinshaw
Journal:  J Infect Dis       Date:  1984-12       Impact factor: 5.226

7.  Evaluation of live avian-human reassortant influenza A H3N2 and H1N1 virus vaccines in seronegative adult volunteers.

Authors:  M H Snyder; M L Clements; R F Betts; R Dolin; A J Buckler-White; E L Tierney; B R Murphy
Journal:  J Clin Microbiol       Date:  1986-05       Impact factor: 5.948

8.  Virulence of avian influenza A viruses for squirrel monkeys.

Authors:  B R Murphy; V S Hinshaw; D L Sly; W T London; N T Hosier; F T Wood; R G Webster; R M Chanock
Journal:  Infect Immun       Date:  1982-09       Impact factor: 3.441

9.  Evaluation of avian-human reassortant influenza A/Washington/897/80 x A/Pintail/119/79 virus in monkeys and adult volunteers.

Authors:  M L Clements; M H Snyder; A J Buckler-White; E L Tierney; W T London; B R Murphy
Journal:  J Clin Microbiol       Date:  1986-07       Impact factor: 5.948
  9 in total
  5 in total

1.  A recombinant human parainfluenza virus type 3 (PIV3) in which the nucleocapsid N protein has been replaced by that of bovine PIV3 is attenuated in primates.

Authors:  J E Bailly; J M McAuliffe; A P Durbin; W R Elkins; P L Collins; B R Murphy
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

2.  A Dose-finding Study of a Wild-type Influenza A(H3N2) Virus in a Healthy Volunteer Human Challenge Model.

Authors:  Alison Han; Lindsay M Czajkowski; Amanda Donaldson; Holly Ann Baus; Susan M Reed; Rani S Athota; Tyler Bristol; Luz Angela Rosas; Adriana Cervantes-Medina; Jeffery K Taubenberger; Matthew J Memoli
Journal:  Clin Infect Dis       Date:  2019-11-27       Impact factor: 9.079

3.  Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers.

Authors:  M L Clements; E K Subbarao; L F Fries; R A Karron; W T London; B R Murphy
Journal:  J Clin Microbiol       Date:  1992-03       Impact factor: 5.948

4.  Bovine parainfluenza virus type 3 (BPIV3) fusion and hemagglutinin-neuraminidase glycoproteins make an important contribution to the restricted replication of BPIV3 in primates.

Authors:  A C Schmidt; J M McAuliffe; A Huang; S R Surman; J E Bailly; W R Elkins; P L Collins; B R Murphy; M H Skiadopoulos
Journal:  J Virol       Date:  2000-10       Impact factor: 5.103

Review 5.  New aspects of influenza viruses.

Authors:  M W Shaw; N H Arden; H F Maassab
Journal:  Clin Microbiol Rev       Date:  1992-01       Impact factor: 26.132
  5 in total

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