Literature DB >> 3760086

Estimation of tetrahydrobiopterin and other pterins in cerebrospinal fluid using reversed-phase high-performance liquid chromatography with electrochemical and fluorescence detection.

D W Howells, I Smith, K Hyland.   

Abstract

We describe an isocratic, reversed-phase high-performance liquid chromatographic method for the simultaneous measurement of fully oxidised, dihydro- and tetrahydropterins in cerebrospinal fluid. Tetrahydrobiopterin is detected electrochemically using an ESA Coulochem detector in the redox mode. Dihydropterins are detected by fluorescence following post-column electrochemical oxidation, and fully oxidised pterins by their natural fluorescence. Apart from addition of antioxidants, no sample preparation is required. Comparison is made with methods requiring chemical oxidation for detection of tetrahydrobiopterin. Some results on children with neurological disease are presented.

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Year:  1986        PMID： 3760086     DOI： 10.1016/s0378-4347(00)83594-x

Source DB:  PubMed          Journal:  J Chromatogr


  17 in total

1.  HPLC analysis of tetrahydrobiopterin and its pteridine derivatives using sequential electrochemical and fluorimetric detection: application to tetrahydrobiopterin autoxidation and chemical oxidation.

Authors:  Roberto Biondi; Giuseppe Ambrosio; Francesco De Pascali; Isabella Tritto; Enrico Capodicasa; Lawrence J Druhan; Craig Hemann; Jay L Zweier
Journal:  Arch Biochem Biophys       Date:  2012-01-20       Impact factor: 4.013

2.  Simultaneous determination of all forms of biopterin and neopterin in cerebrospinal fluid.

Authors:  Pierre Guibal; Nathalie Lévêque; Diane Doummar; Nicolas Giraud; Emmanuel Roze; Diana Rodriguez; Rémy Couderc; Thierry Billette De Villemeur; Fathi Moussa
Journal:  ACS Chem Neurosci       Date:  2014-04-08       Impact factor: 4.418

3.  Biopterins in arginase, dihydropteridine reductase and phenylalanine hydroxylase deficiency.

Authors:  K Hyland; I Smith; J V Leonard
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-02       Impact factor: 10.154

4.  Tetrahydrobiopterin deficiency and brain nitric oxide synthase in the hph1 mouse.

Authors:  M P Brand; S J Heales; J M Land; J B Clark
Journal:  J Inherit Metab Dis       Date:  1995       Impact factor: 4.982

5.  GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.

Authors:  Amy L Tatham; Mark J Crabtree; Nicholas Warrick; Shijie Cai; Nicholas J Alp; Keith M Channon
Journal:  J Biol Chem       Date:  2009-03-13       Impact factor: 5.157

6.  Serotonin metabolites in the cerebrospinal fluid in sudden infant death syndrome.

Authors:  Ingvar J Rognum; Hoa Tran; Elisabeth A Haas; Keith Hyland; David S Paterson; Robin L Haynes; Kevin G Broadbelt; Brian J Harty; Othon Mena; Henry F Krous; Hannah C Kinney
Journal:  J Neuropathol Exp Neurol       Date:  2014-02       Impact factor: 3.685

7.  Sepiapterin reductase deficiency in a 2-year-old girl with incomplete response to treatment during short-term follow-up.

Authors:  K Kusmierska; E E W Jansen; C Jakobs; K Szymanska; E Malunowicz; D Meilei; B Thony; N Blau; J Tryfon; D Rokicki; E Pronicka; J Sykut-Cegielska
Journal:  J Inherit Metab Dis       Date:  2009-01-07       Impact factor: 4.982

8.  Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice.

Authors:  Malarvannan Pannirselvam; Valerie Simon; Subodh Verma; Todd Anderson; Chris R Triggle
Journal:  Br J Pharmacol       Date:  2003-10       Impact factor: 8.739

9.  Ca2+/calmodulin-dependent nitric oxide synthase activity in the human cervix carcinoma cell line ME-180.

Authors:  G Werner-Felmayer; E R Werner; D Fuchs; A Hausen; B Mayer; G Reibnegger; G Weiss; H Wachter
Journal:  Biochem J       Date:  1993-01-15       Impact factor: 3.857

10.  Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence.

Authors:  Katrin Watschinger; Markus A Keller; Albin Hermetter; Georg Golderer; Gabriele Werner-Felmayer; Ernst R Werner
Journal:  Biol Chem       Date:  2009-01       Impact factor: 3.915
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