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Literature DB >> 3756356

Acquired refractory anaemia with excess of blasts of promegakaryoblastic type.

S Woessner, R Lafuente, L Florensa, R M Vilá, J Sans-Sabrafen.

Abstract

A case of acquired refractory anaemia with excess of blasts (RAEB) of the promegakaryoblastic type is described. The promegakaryoblastic origin was demonstrated by means of ultrastructural cytochemistry (platelet peroxidase) and immunological methods. The blasts were also 5'-Nucleotidase positive. After a stable course over 2.5 years the patient died from hematological failure, his marrow demonstrating a high degree of fibrosis.

Entities: Disease Gene Species

Mesh：

Year: 1986 PMID： 3756356 DOI： 10.1007/bf00320887

Source DB: PubMed Journal: Blut ISSN： 0006-5242

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References

10 in total

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10 in total

Acquired refractory anaemia with excess of blasts of promegakaryoblastic type.

1. Megakaryoblastic transformation of chronic granulocytic leukaemia. An electron microscopy and cytochemial study.

2. The blast crisis of chronic granulocytic leukaemia: megakaryoblastic nature of cells as revealed by the presence of platelet-peroxidase--a cytochemical ultrastructural study.

3. Fine structure and peroxidase activity of circulating micromegakaryoblasts and platelets in a case of acute myelofibrosis.

4. Simultaneous detection of membrane markers with monoclonal antibodies and peroxidatic activities in leukaemia: ultrastructural analysis using a new method of fixation preserving the platelet peroxidase.

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10. Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). A report of the French-American-British Cooperative Group.