Literature DB >> 3754638

Escape behavior produced by the blockade of glutamic acid decarboxylase (GAD) in mesencephalic central gray or medial hypothalamus.

M L Brandao, G Di Scala, M J Bouchet, P Schmitt.   

Abstract

Microinjections into the mesencephalic central gray (CG) or the medial hypothalamus (MH) of three drugs (L-allylglycine, Semicarbazide or 4,5 dihydroxy-isophtalic acid) known to block glutamic acid decarboxylase (GAD) produced a dose-dependent behavioral activation accompanied by jumps. These effects are qualitatively similar to those produced by microinjections of SR 95103 (a GABA-A receptor antagonist) at the same site. These findings suggest that, at both the level of the CG and the MH, gamma-aminobutyric acid (GABA) tonically inhibits a neuronal substrate involved in the generation of flight reactions.

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Year:  1986        PMID： 3754638     DOI： 10.1016/0091-3057(86)90547-2

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  10 in total

1.  Lesion of the ventral periaqueductal gray reduces conditioned fear but does not change freezing induced by stimulation of the dorsal periaqueductal gray.

Authors:  D M Vianna; F G Graeff; J Landeira-Fernandez; M L Brandão
Journal:  Learn Mem       Date:  2001 May-Jun       Impact factor: 2.460

Review 2.  Pharmacological and biochemical aspects of GABAergic neurotransmission: pathological and neuropsychobiological relationships.

Authors:  Renê Oliveira Beleboni; Ruither Oliveira Gomes Carolino; Andrea Baldocchi Pizzo; Lissandra Castellan-Baldan; Joaquim Coutinho-Netto; Wagner Ferreira dos Santos; Norberto Cysne Coimbra
Journal:  Cell Mol Neurobiol       Date:  2004-12       Impact factor: 5.046

3.  5-HT2 receptor mechanisms of the dorsal periaqueductal gray in the conditioned and unconditioned fear in rats.

Authors:  Luciana Chrystine Oliveira; Ana Carolina Broiz; Carlos Eduardo de Macedo; J Landeira-Fernandez; Marcus Lira Brandão
Journal:  Psychopharmacology (Berl)       Date:  2007-01-05       Impact factor: 4.530

4.  Midbrain central gray GABAA receptor activation enhances, and blockade reduces, sexual behavior in the female rat.

Authors:  M M McCarthy; D W Pfaff; S Schwartz-Giblin
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

5.  Amygdala selectively modulates defensive responses evoked from the superior colliculus in non-human primates.

Authors:  Patrick A Forcelli; Jacqueline T DesJardin; Elizabeth A West; Angela L Holmes; Catherine Elorette; Laurie L Wellman; Ludise Malkova
Journal:  Soc Cogn Affect Neurosci       Date:  2016-08-10       Impact factor: 3.436

6.  Regulatory interactions of stress and reward on rat forebrain opioidergic and GABAergic circuitry.

Authors:  A M Christiansen; J P Herman; Y M Ulrich-Lai
Journal:  Stress       Date:  2011-03       Impact factor: 3.493

7.  Hypothalamic GABAA receptor blockade modulates cerebral cortical systems sensitive to acute stressors.

Authors:  J R Inglefield; C K Kellogg
Journal:  Psychopharmacology (Berl)       Date:  1994-11       Impact factor: 4.530

8.  Effects of microinjections of mu and kappa receptor agonists into the dorsal periaqueductal gray of rats submitted to the plus maze test.

Authors:  V Motta; K Penha; M L Brandão
Journal:  Psychopharmacology (Berl)       Date:  1995-08       Impact factor: 4.530

9.  Ventromedial hypothalamic neurons control a defensive emotion state.

Authors:  Prabhat S Kunwar; Moriel Zelikowsky; Ryan Remedios; Haijiang Cai; Melis Yilmaz; Markus Meister; David J Anderson
Journal:  Elife       Date:  2015-03-06       Impact factor: 8.140

10.  Panic-like defensive behavior but not fear-induced antinociception is differently organized by dorsomedial and posterior hypothalamic nuclei of Rattus norvegicus (Rodentia, Muridae).

Authors:  A F Biagioni; J A Silva; N C Coimbra
Journal:  Braz J Med Biol Res       Date:  2012-03-22       Impact factor: 2.590
  10 in total

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