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Literature DB >> 3754009

A computer programme for estimation of genetic risk in X linked disorders, combining pedigree and DNA probe data with other conditional information.

Abstract

A computer programme is presented for calculating the recurrence risk in X linked disorders, combining pedigree and DNA probe data with other conditional information such as carrier detection tests. The methods of computation are shown in the given examples. The programme can be used with either a single DNA probe or two 'flanking' DNA probes for both familial and isolated case pedigrees. For isolated case families the mutation rate at the disease locus can be taken into account in conjunction with the DNA probe data.

Entities: Disease

Mesh：

Substances：
DNA

Year: 1986 PMID： 3754009 PMCID： PMC1049539 DOI： 10.1136/jmg.23.1.40

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

8 in total

1. New linkage data for the X-linked types of muscular dystrophy and G6PD variants, colour blindness, and Xg blood groups.

Authors: M Zatz; S B Itskan; R Sanger; O Frota-Pessoa; P H Saldanha
Journal: J Med Genet Date: 1974-12 Impact factor: 6.318

2. How many polymorphic genes will it take to span the human genome?

Authors: K Lange; M Boehnke
Journal: Am J Hum Genet Date: 1982-11 Impact factor: 11.025

3. The use of linked DNA polymorphisms for genotype prediction in families with Duchenne muscular dystrophy.

Authors: P S Harper; T O'Brien; J M Murray; K E Davies; P Pearson; R Williamson
Journal: J Med Genet Date: 1983-08 Impact factor: 6.318

4. Localisation of the Becker muscular dystrophy gene on the short arm of the X chromosome by linkage to cloned DNA sequences.

Authors: H M Kingston; M Sarfarazi; N S Thomas; P S Harper
Journal: Hum Genet Date: 1984 Impact factor: 4.132

5. Strategies for multilocus linkage analysis in humans.

Authors: G M Lathrop; J M Lalouel; C Julier; J Ott
Journal: Proc Natl Acad Sci U S A Date: 1984-06 Impact factor: 11.205

Review 6. Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

Authors: D Botstein; R L White; M Skolnick; R W Davis
Journal: Am J Hum Genet Date: 1980-05 Impact factor: 11.025

7. Carrier detection in Becker muscular dystrophy using creatine kinase estimation and DNA analysis.

Authors: H M Kingston; M Sarfarazi; R G Newcombe; N Willis; P S Harper
Journal: Clin Genet Date: 1985-04 Impact factor: 4.438

8. Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosome.

Authors: K E Davies; P L Pearson; P S Harper; J M Murray; T O'Brien; M Sarfarazi; R Williamson
Journal: Nucleic Acids Res Date: 1983-04-25 Impact factor: 16.971

8 in total

6 in total

1. Duchenne muscular dystrophy in Wales: impact of DNA linkage analysis and cDNA deletion screening.

Authors: A M Norman; M Upadhyaya; N S Thomas; K Roberts; P S Harper
Journal: J Med Genet Date: 1989-09 Impact factor: 6.318

2. Predicting genotypes at loci for autosomal recessive disorders using linked genetic markers: application to Wilson's disease.

Authors: L A Farrer; B Bonne-Tamir; M Frydman; A Magazanik; K K Kidd; A M Bowcock; L L Cavalli-Sforza
Journal: Hum Genet Date: 1988-06 Impact factor: 4.132