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Literature DB >> 3753772

A multiple sequence alignment program.

Abstract

A program is described for simultaneously aligning two or more molecular sequences which is based on first finding common segments above a specified length and then piecing these together to maximize an alignment scoring function. Optimal as well as near-optimal alignments are found, and there is also provided a means for randomizing the given sequences for testing the statistical significance of an alignment. Alignments may be made in the original alphabets of the sequences or in user-specified alternate ones to take advantage of chemical similarities (such as hydrophobic-hydrophilic).

Mesh：

Year: 1986 PMID： 3753772 PMCID： PMC339419 DOI： 10.1093/nar/14.1.363

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

3 in total

1. Simultaneous comparison of three protein sequences.

Authors: M Murata; J S Richardson; J L Sussman
Journal: Proc Natl Acad Sci U S A Date: 1985-05 Impact factor: 11.205

2. Sequence similarity ('homology') searching for molecular biologists.

Authors: D Davison
Journal: Bull Math Biol Date: 1985 Impact factor: 1.758

3. An efficient method for finding repeats in molecular sequences.

Authors: H M Martinez
Journal: Nucleic Acids Res Date: 1983-07-11 Impact factor: 16.971

3 in total

42 in total

1. Sequences of human immunoglobulin switch regions: implications for recombination and transcription.

Authors: F C Mills; J S Brooker; R D Camerini-Otero
Journal: Nucleic Acids Res Date: 1990-12-25 Impact factor: 16.971

2. cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences.

Authors: J D Stubbs; C Lekutis; K L Singer; A Bui; D Yuzuki; U Srinivasan; G Parry
Journal: Proc Natl Acad Sci U S A Date: 1990-11 Impact factor: 11.205

10. A transposition of the reverse transcriptase gene reveals unexpected structural homology to E. coli DNA polymerase I.

Authors: E W Taylor; J Jaakkola
Journal: Genetica Date: 1991 Impact factor: 1.082

A multiple sequence alignment program.

1. Simultaneous comparison of three protein sequences.

2. Sequence similarity ('homology') searching for molecular biologists.

3. An efficient method for finding repeats in molecular sequences.

1. Sequences of human immunoglobulin switch regions: implications for recombination and transcription.

2. cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences.

3. A survey of multiple sequence comparison methods.

4. Phylogenetic and physical analysis of the 5' leader RNA sequences of avian retroviruses.

5. Consistency of optimal sequence alignments.

6. Pertussis toxin has eukaryotic-like carbohydrate recognition domains.

7. A reinforced merging methodology for mapping unique peptide motifs in members of protein families.

8. An efficient algorithm for identifying matches with errors in multiple long molecular sequences.

9. A multiple sequence comparison method.

10. A transposition of the reverse transcriptase gene reveals unexpected structural homology to E. coli DNA polymerase I.