Literature DB >> 3753036

A novel synthetic vitamin-A-like compound (a polyprenoic acid derivative: E-5166) inhibits UVB-stimulated epidermal ornithine decarboxylase activity.

O Nemoto, H Koizumi, T Aoyagi.   

Abstract

Irradiation of skin with ultraviolet B (UVB) stimulates epidermal activity of ornithine decarboxylase (ODC), a rate limiting polyamine biosynthesing enzyme. The maximum stimulation of ODC activity by UVB was found at 24 after irradiation. Systemic administration of a polyprenoic acid derivative (E-5166) significantly inhibited the UVB-stimulated ODC activity in a dose-dependent manner. The inhibitory effect of E-5166 on the UVB-stimulated ODC activity was found to begin at 5 mg/kg body weight. These results indicate that because it inhibits ODC activity E-5166 can be utilized for the treatment of hyperproliferative skin diseases.

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Year:  1986        PMID： 3753036     DOI： 10.1007/bf00418171

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  18 in total

1.  Prostaglandin and DNA synthesis in human skin: possible relationship to ultraviolet light effects.

Authors:  W H Eaglstein; G D Weinstein
Journal:  J Invest Dermatol       Date:  1975-06       Impact factor: 8.551

2.  Pharmacologic agents released in ultraviolet inflammation studied by continuous skin pefusion.

Authors:  M W Greaves; J Sondergaard
Journal:  J Invest Dermatol       Date:  1970-05       Impact factor: 8.551

3.  A novel cellular retinoid-binding protein, F-type, in hepatocellular carcinoma.

Authors:  Y Muto; M Omori
Journal:  Ann N Y Acad Sci       Date:  1981-02-27       Impact factor: 5.691

4.  Ultraviolet light induces epidermal ornithine decarboxylase activity.

Authors:  M Lowe; A K Verma; R K Boutwell
Journal:  J Invest Dermatol       Date:  1978-12       Impact factor: 8.551

5.  Retinol inhibition of ornithine decarboxylase induction and G1 progression in Chinese hamster ovary cells.

Authors:  M K Haddox; K F Scott; D H Russell
Journal:  Cancer Res       Date:  1979-12       Impact factor: 12.701

6.  Retinoids increase transglutaminase activity and inhibit ornithine decarboxylase activity in Chinese hamster ovary cells and in melanoma cells stimulated to differentiate.

Authors:  K F Scott; F L Meyskens; D H Russell
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

7.  Retinoic acid modulation of ultraviolet light-induced epidermal ornithine decarboxylase activity.

Authors:  N J Lowe; J Breeding
Journal:  J Invest Dermatol       Date:  1982-02       Impact factor: 8.551

8.  Ornithine decarboxylase activity is inhibited by epidermal polyamine-dependent protein kinase-mediated phosphorylation.

Authors:  O Nemoto; T Aoyagi; Y Miura
Journal:  J Invest Dermatol       Date:  1984-10       Impact factor: 8.551

9.  Protein factor which induces conversion between Physarum ornithine decarboxylase forms in vitro.

Authors:  J L Mitchell; T A Augustine; J M Wilson
Journal:  Biochim Biophys Acta       Date:  1981-01-15

10.  Ultraviolet light depletes surface markers of Langerhans cells.

Authors:  W Aberer; G Schuler; G Stingl; H Hönigsmann; K Wolff
Journal:  J Invest Dermatol       Date:  1981-03       Impact factor: 8.551
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