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Literature DB >> 3747644

The bioavailability of Tamoplex (tamoxifen). Part 1. A pilot study.

J G McVie, G P Simonetti, D Stevenson, R J Briggs, P J Guelen, D de Vos.

Abstract

Tamoxifen and N-desmethyltamoxifen plasma concentrations were found to be similar after a first single dose and during two months therapy with Tamoplex or Nolvadex in groups of 6 and 8 patients, respectively. Single dose absorption results in 10 healthy male volunteers demonstrated bioequivalence of Tamoplex and Nolvadex 10 mg tablets. A large interindividual variation in tamoxifen absorption data was observed, probably related to the dominating metabolic clearance of tamoxifen.

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Year: 1986 PMID： 3747644

Source DB: PubMed Journal: Methods Find Exp Clin Pharmacol ISSN： 0379-0355

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Cited

7 in total

1. Solidified self-nanoemulsifying formulation for oral delivery of combinatorial therapeutic regimen: part I. Formulation development, statistical optimization, and in vitro characterization.

Authors: Amit K Jain; Kaushik Thanki; Sanyog Jain
Journal: Pharm Res Date: 2013-12-03 Impact factor: 4.200

7. Solidified self-nanoemulsifying formulation for oral delivery of combinatorial therapeutic regimen: part II in vivo pharmacokinetics, antitumor efficacy and hepatotoxicity.

Authors: Amit K Jain; Kaushik Thanki; Sanyog Jain
Journal: Pharm Res Date: 2013-10-18 Impact factor: 4.200

7 in total

The bioavailability of Tamoplex (tamoxifen). Part 1. A pilot study.

1. Solidified self-nanoemulsifying formulation for oral delivery of combinatorial therapeutic regimen: part I. Formulation development, statistical optimization, and in vitro characterization.

2. The bioavailability of three altretamine formulations.

3. The bioavailability of Tamoplex (tamoxifen). Part 3. A steady-state study in breast cancer patients.

Review 4. Clinical pharmacokinetics of drugs used in the treatment of breast cancer.

Review 5. Pharmacokinetics of selective estrogen receptor modulators.

Review 6. Tamoxifen. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic use.

7. Solidified self-nanoemulsifying formulation for oral delivery of combinatorial therapeutic regimen: part II in vivo pharmacokinetics, antitumor efficacy and hepatotoxicity.