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Literature DB >> 3746382

Putrescine metabolism in human brain tumors.

S S Goldman, N D Volkow, J Brodie, E S Flamm.

Abstract

The metabolism of the polyamines, putrescine, spermidine and spermine, was studied in human brain and brain tumors. Samples of brain and tumors were incubated with 3H-putrescine and the amounts of labeled polyamines were measured. The amount of putrescine conversion was found to be greater in tumors that in normal brain samples. Furthermore, the metabolism of putrescine in brain tumors was related to tumor type and appeared to correlate with the degree of malignancy. The significance of these findings with regard to positron emission tomographic scanning and therapy of patients with malignant gliomas is discussed.

Entities: Chemical Disease Species

Mesh：

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Year: 1986 PMID： 3746382 DOI： 10.1007/bf02157998

Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130

29 in total

1. THE DETERMINATION AND DISTRIBUTION OF POLYAMINES IN MAMMALIAN NERVOUS SYSTEM.

Authors: H SHIMIZU; Y KAKIMOTO; I SANO
Journal: J Pharmacol Exp Ther Date: 1964-02 Impact factor: 4.030

2. The Chemical Constitution of Spermine. I. The Isolation of Spermine from Animal Tissues, and the Preparation of its Salts.

Authors: H W Dudley; M C Rosenheim; O Rosenheim
Journal: Biochem J Date: 1924 Impact factor: 3.857

3. Capillary transport of amino acids in the developing brain.

Authors: H Sershen; A Lajtha
Journal: Exp Neurol Date: 1976-11 Impact factor: 5.330

4. Metabolism of putrescine in neuroblastoma and glioma cells during culture.

Authors: K Sobue; T Nakajima
Journal: J Biochem Date: 1977-10 Impact factor: 3.387

5. Polyamine metabolism and function in brain.

Authors: N Seiler
Journal: Neurochem Int Date: 1981 Impact factor: 3.921

6. Polyamine metabolism in a rat brain tumor cell line: its relationship to the growth rate.

Authors: O Heby; L J Marton; C B Wilson; H M Martinez
Journal: J Cell Physiol Date: 1975-12 Impact factor: 6.384

7. Cerebrospinal fluid polyamines in patients with Glioblastoma multiforme and anaplastic astrocytoma.

Authors: D S Fulton; V A Levin; W P Lubich; C B Wilson; L J Marton
Journal: Cancer Res Date: 1980-09 Impact factor: 12.701

8. Brain tumor evaluation using Rb-82 and positron emission tomography.

Authors: C K Yen; Y Yano; T F Budinger; R P Friedland; S E Derenzo; R H Huesman; H A O'Brien
Journal: J Nucl Med Date: 1982-06 Impact factor: 10.057

Review 9. Polyamine metabolism and function.

Authors: A E Pegg; P P McCann
Journal: Am J Physiol Date: 1982-11

10. Tumor selective enhancement of radioactivity uptake in mice treated with alpha-difluoromethylornithine prior to administration of 14C-putrescine.

Authors: J E Chaney; K Kobayashi; R Goto; G A Digenis
Journal: Life Sci Date: 1983-03-14 Impact factor: 5.037

7 in total

7. The metastatic stage-dependent mucosal expression of sialic acid is a potential marker for targeting colon cancer with cationic polymers.

Authors: Abdel Kareem Azab; Jackie Kleinstern; Morris Srebnik; Abraham Rubinstein
Journal: Pharm Res Date: 2007-10-25 Impact factor: 4.200

7 in total

Putrescine metabolism in human brain tumors.

1. THE DETERMINATION AND DISTRIBUTION OF POLYAMINES IN MAMMALIAN NERVOUS SYSTEM.

2. The Chemical Constitution of Spermine. I. The Isolation of Spermine from Animal Tissues, and the Preparation of its Salts.

3. Capillary transport of amino acids in the developing brain.

4. Metabolism of putrescine in neuroblastoma and glioma cells during culture.

5. Polyamine metabolism and function in brain.

6. Polyamine metabolism in a rat brain tumor cell line: its relationship to the growth rate.

7. Cerebrospinal fluid polyamines in patients with Glioblastoma multiforme and anaplastic astrocytoma.

8. Brain tumor evaluation using Rb-82 and positron emission tomography.

Review 9. Polyamine metabolism and function.

10. Tumor selective enhancement of radioactivity uptake in mice treated with alpha-difluoromethylornithine prior to administration of 14C-putrescine.

1. Polyamine metabolism in brain tumours: diagnostic relevance of quantitative biochemistry.

2. Measurements of CSF biochemical tumor markers in patients with meningeal carcinomatosis and brain tumors.

Review 3. 11C-L-methionine positron emission tomography in the clinical management of cerebral gliomas.

4. Red blood cell polyamines as a diagnostic indicator of glioma presence and recurrence.

5. Polyamine metabolism in gliomas.

6. Polyamines block Ca(2+)-activated K+ channels in pituitary tumor cells (GH3).

7. The metastatic stage-dependent mucosal expression of sialic acid is a potential marker for targeting colon cancer with cationic polymers.