Literature DB >> 20487812

Polyamine metabolism and function in brain.

N Seiler1.   

Abstract

Putrescine, spermidine and spermine are simple alipathic polycations of ubiquitous occurrence. The pathways of biosynthesis and catabolism, and changes of the concentrations of these compounds in brain under various conditions are discussed. The pharmacological properties of the polyamines have not yet revealed functions which are characteristic only for the CNS, but preliminary evidence suggests structural roles in membranes and a modulatory function in certain neuronal systems.

Entities:  

Year:  1981        PMID： 20487812     DOI： 10.1016/0197-0186(81)90027-9

Source DB:  PubMed          Journal:  Neurochem Int        ISSN： 0197-0186            Impact factor:   3.921


  15 in total

Review 1.  Suicide and the polyamine system.

Authors:  Jeffrey A Gross; Gustavo Turecki
Journal:  CNS Neurol Disord Drug Targets       Date:  2013-11       Impact factor: 4.388

2.  On the metabolism of ornithine in synaptosomal preparations.

Authors:  S P Lapinjoki; A E Pajunen; A E Pulkka; R S Piha
Journal:  Neurochem Res       Date:  1982-06       Impact factor: 3.996

3.  L-arginine and Alzheimer's disease.

Authors:  Jing Yi; Laura L Horky; Avi L Friedlich; Ying Shi; Jack T Rogers; Xudong Huang
Journal:  Int J Clin Exp Pathol       Date:  2008-10-02

4.  Decreased hyperammonaemia and orotic aciduria due to inactivation of ornithine aminotransferase in mice with a hereditary abnormal ornithine carbamoyltransferase.

Authors:  N Seiler; C Grauffel; G Daune-Anglard; S Sarhan; B Knödgen
Journal:  J Inherit Metab Dis       Date:  1994       Impact factor: 4.982

5.  Putrescine metabolism in human brain tumors.

Authors:  S S Goldman; N D Volkow; J Brodie; E S Flamm
Journal:  J Neurooncol       Date:  1986       Impact factor: 4.130

Review 6.  Endogenous ornithine in search for CNS functions and therapeutic applications.

Authors:  N Seiler; G Daune-Anglard
Journal:  Metab Brain Dis       Date:  1993-09       Impact factor: 3.584

7.  Polyamine metabolism in gliomas.

Authors:  R I Ernestus; G Röhn; R Schröder; T Els; J Y Lee; N Klug; W Paschen
Journal:  J Neurooncol       Date:  1996-08       Impact factor: 4.130

8.  Relationship between putrescine content and density of ischemic cell damage in the brain of mongolian gerbils: effect of nimodipine and barbiturate.

Authors:  W Paschen; J Hallmayer; G Röhn
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088

9.  Modulation of neuronal voltage-activated calcium and sodium channels by polyamines and pH.

Authors:  Wenyan Chen; Mark T Harnett; Stephen M Smith
Journal:  Channels (Austin)       Date:  2007-09-05       Impact factor: 2.581

10.  Polyamines in human brain tumors. A correlative study between tumor, cerebrospinal fluid and red blood cell free polyamine levels.

Authors:  J P Moulinoux; V Quemener; M Le Calve; M Chatel; F Darcel
Journal:  J Neurooncol       Date:  1984       Impact factor: 4.130
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