Literature DB >> 3743773

Translational regulation of ornithine decarboxylase by polyamines.

L Persson, I Holm, O Heby.   

Abstract

The activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the polyamine biosynthetic pathway, is dramatically increased in proliferating cells. In addition to transcriptional regulation of ODC, the present study shows that the enzyme is regulated at the translational level by putrescine and spermidine. ODC synthesis is inhibited by an increase and stimulated by a decrease in their cellular content. Spermidine is a more potent negative regulator than is putrescine. The effects of polyamines on ODC synthesis were not attributable to changes in the cellular content of ODC mRNA, thus demonstrating regulation at the translational level.

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Year:  1986        PMID： 3743773     DOI： 10.1016/0014-5793(86)80892-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  23 in total

Review 1.  Biological significance of agmatine, an endogenous ligand at imidazoline binding sites.

Authors:  W Raasch; U Schäfer; J Chun; P Dominiak
Journal:  Br J Pharmacol       Date:  2001-07       Impact factor: 8.739

2.  Regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in a polyamine auxotrophic cell line.

Authors:  F Svensson; L Persson
Journal:  Mol Cell Biochem       Date:  1996-09-20       Impact factor: 3.396

3.  Constitutive expression of growth-related mRNAs in proliferating and nonproliferating lung epithelial cells in primary culture: evidence for growth-dependent translational control.

Authors:  A Clement; J Campisi; S R Farmer; J S Brody
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

4.  Polyamine-mediated regulation of mouse ornithine decarboxylase is posttranslational.

Authors:  T van Daalen Wetters; M Macrae; M Brabant; A Sittler; P Coffino
Journal:  Mol Cell Biol       Date:  1989-12       Impact factor: 4.272

5.  Effect of 1-amino-oxy-3-aminopropane on polyamine metabolism and growth of L1210 cells.

Authors:  R Poulin; J A Secrist; A E Pegg
Journal:  Biochem J       Date:  1989-10-01       Impact factor: 3.857

6.  The effect of amino acids, monoamines and polyamines on pyruvate dehydrogenase activity in mitochondria from rat adipocytes.

Authors:  F L Kiechle; H Malinski; D M Dandurand; J B McGill
Journal:  Mol Cell Biochem       Date:  1990-03-27       Impact factor: 3.396

7.  Polyamines regulate the expression of ornithine decarboxylase antizyme in vitro by inducing ribosomal frame-shifting.

Authors:  E Rom; C Kahana
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

8.  Forced expression of antizyme abolishes ornithine decarboxylase activity, suppresses cellular levels of polyamines and inhibits cell growth.

Authors:  Y Murakami; S Matsufuji; Y Miyazaki; S Hayashi
Journal:  Biochem J       Date:  1994-11-15       Impact factor: 3.857

9.  Selective regulation of S-adenosylmethionine decarboxylase activity by the spermine analogue 6-spermyne.

Authors:  C W Porter; J McManis; D Lee; R J Bergeron
Journal:  Biochem J       Date:  1988-09-01       Impact factor: 3.857

10.  Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cells.

Authors:  R Madhubala; J A Secrist; A E Pegg
Journal:  Biochem J       Date:  1988-08-15       Impact factor: 3.857
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