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Literature DB >> 3743628

Spiramycin has no effect on serum theophylline in asthmatic patients.

D Debruyne, A Jehan, M C Bigot, B Lechevalier, J N Prevost, M Moulin.

Abstract

Fifteen asthmatic patients receiving a sustained-release theophylline preparation were also treated with spiramycin for at least 5 days. The macrolide antibiotic had no significant effect on the steady-state theophylline concentration, unlike erythromycin and troleandomycin, which belong to the same class of antibiotics. The latter two drugs have different chemical structures and decrease theophylline clearance. Accordingly, spiramycin comedication does not require special serum level drug monitoring or adjustment of the dose of theophylline.

Entities: Chemical Species

Mesh：

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Year: 1986 PMID： 3743628 DOI： 10.1007/bf00607971

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

14 in total

1. Comparison of serum theophylline levels with plain and slow-release aminophylline in patient with airway obstruction.

Authors: A Muittari; H Allonen
Journal: J Int Med Res Date: 1981 Impact factor: 1.671

2. [Influence of a new macrolide, midecamycin on theophylline pharmacokinetics (author's transl)].

Authors: J Lavarenne; M Paire; O Talon
Journal: Therapie Date: 1981 Jul-Aug Impact factor: 2.070

3. Effect of erythromycin stearate on serum theophylline concentration in patients with chronic obstructive lung disease.

Authors: B M Stults; J Felice-Johnson; M D Higbee; K Hardigan
Journal: South Med J Date: 1983-06 Impact factor: 0.954

4. Efficacy of a 12-hour sustained-release preparation in maintaining therapeutic serum theophylline levels in asthmatic children.

Authors: H W Kelly; S Murphy
Journal: Pediatrics Date: 1980-07 Impact factor: 7.124

Review 5. Pharmacokinetic drug interactions with theophylline.

Authors: J H Jonkman; R A Upton
Journal: Clin Pharmacokinet Date: 1984 Jul-Aug Impact factor: 6.447

6. Depression of theophylline elimination by erythromycin.

Authors: K W Renton; J D Gray; O R Hung
Journal: Clin Pharmacol Ther Date: 1981-09 Impact factor: 6.875

7. Formation of an inactive cytochrome P-450 Fe(II)-metabolite complex after administration of troleandomycin in humans.

Authors: D Pessayre; D Larrey; J Vitaux; P Breil; J Belghiti; J P Benhamou
Journal: Biochem Pharmacol Date: 1982-05-01 Impact factor: 5.858

8. Theophylline kinetics and ventilatory flow in bronchial asthma and chronic airflow obstruction: influence of erythromycin.

Authors: C Richer; M Mathieu; H Bah; C Thuillez; P Duroux; J F Giudicelli
Journal: Clin Pharmacol Ther Date: 1982-05 Impact factor: 6.875

Review 2. Influence of endogenous and exogenous effectors on the pharmacokinetics of theophylline. Focus on biotransformation.

Authors: U Tröger; F P Meyer
Journal: Clin Pharmacokinet Date: 1995-04 Impact factor: 6.447

Review 3. Macrolide antibacterials. Drug interactions of clinical significance.

Authors: N A von Rosensteil; D Adam
Journal: Drug Saf Date: 1995-08 Impact factor: 5.606

Review 4. Pharmacokinetic drug interactions of macrolides.

Authors: P Periti; T Mazzei; E Mini; A Novelli
Journal: Clin Pharmacokinet Date: 1992-08 Impact factor: 6.447

4 in total